SCHEMBL10032181

SCHEMBL10032181

Cc1cccc(-c2c3ccccc3c(-c3ccc4ccc(-c5cncc(-c6ccccn6)c5)cc4c3)c3ccccc23)c1

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 4/20 0.44
CYP2A6 P11509 2/20 0.40
TGFBR1 P36897 1/20 0.39
CYP11B2 P19099 3/20 0.39
CYP11B1 P15538 2/20 0.39
CYP17A1 P05093 2/20 0.38
CYP19A1 P11511 1/20 0.38
BCHE P06276 1/20 0.38
ACHE P22303 1/20 0.38
DCTPP1 Q9H773 1/20 0.37
MAPK14 Q16539 1/20 0.37
LMNA P02545 1/20 0.37
MAPT P10636 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
IRAK4 Q9NWZ3 1/20 0.37
ADORA3 P0DMS8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10032477 0.91 GRM5 (0.40) GRM5CYP2A6TGFBR1CYP11B2CYP11B1
SCHEMBL10032169 0.86 MAPK14 (0.47) CYP11B2CYP11B1CYP17A1CYP19A1MAPK14
SCHEMBL10032182 0.86 CYP11B2 (0.55) CYP2A6CYP11B2CYP11B1CYP17A1CYP19A1
SCHEMBL10032606 0.86 KIF11 (0.41) GRM5CYP2A6CYP11B2CYP11B1CYP17A1
SCHEMBL13015754 0.86 CYP11B1 (0.47) GRM5CYP2A6CYP11B2CYP11B1CYP17A1
SCHEMBL10032884 0.86 GRM5 (0.43) GRM5CYP2A6TGFBR1LMNAMAPT
SCHEMBL10032734 0.85 CYP2A6 (0.49) CYP2A6CYP11B2CYP11B1CYP17A1CYP19A1
SCHEMBL10032667 0.85 GRM5 (0.41) GRM5TGFBR1DCTPP1LMNAMAPT
SCHEMBL18174723 0.83 CYP2A6 (0.43) GRM5CYP2A6TGFBR1CYP11B2CYP11B1
SCHEMBL10032727 0.83 TRPV1 (0.41) GRM5CYP2A6CYP11B2CYP11B1CYP17A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012060374-A1 ELECTRON TRANSPORT MATERIAL AND ORGANIC ELECTROLUMINESCENCE ELEMENT USING SAME JNC株式会社 (JP) 2012-05-10 WO disclosed