SCHEMBL10034249

SCHEMBL10034249

Brc1ccc2ccc3cc4[nH]c5cc(-c6ccccc6)ccc5c4c4ccc1c2c34

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 4/20 0.54
CCND1 P24385 4/20 0.54
TNKS2 Q9H2K2 1/20 0.41
FEN1 P39748 1/20 0.39
FGFR1 P11362 1/20 0.38
JAK2 O60674 1/20 0.37
GPR17 Q13304 1/20 0.35
TTK P33981 1/20 0.34
ALDH1A1 P00352 1/20 0.34
MAPK1 P28482 1/20 0.34
CHEK1 O14757 2/20 0.34
WEE1 P30291 1/20 0.34
PTGES O14684 1/20 0.34
IMPDH2 P12268 1/20 0.33
NPC1 O15118 1/20 0.33
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
GAA P10253 1/20 0.33
MAPT P10636 1/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2601601 1.00 CDK4 (0.54) CDK4CCND1TNKS2FEN1FGFR1
SCHEMBL10034236 0.85 CDK4 (0.45) CDK4CCND1ALDH1A1IMPDH2KDM4E
SCHEMBL2601572 0.85 CDK4 (0.45) CDK4CCND1ALDH1A1IMPDH2KDM4E
SCHEMBL14460559 0.84 CDK4 (0.43) CDK4CCND1TNKS2FEN1FGFR1
SCHEMBL15780144 0.83 CDK4 (0.54) CDK4CCND1TNKS2FEN1FGFR1
Biphenyl SCHEMBL27806904 0.78 ALDH1A1 (0.42) CDK4CCND1ALDH1A1MAPK1KDM4E
SCHEMBL27014722 0.78 CDK4 (0.58) CDK4CCND1TNKS2FEN1FGFR1
SCHEMBL14460602 0.77 CDK4 (0.43) CDK4CCND1TNKS2JAK2NPC1
SCHEMBL28806414 0.77 CYP1A2 (0.44) ALDH1A1MAPK1GRIN2DGRIN2AGRIN2B
SCHEMBL14330620 0.75 ADORA3 (0.53) CDK4CCND1ALDH1A1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8455867-B2 Organic light-emitting device SAMSUNG DISPLAY CO., LTD. (KR) 2013-06-04 US disclosed
US-8455867-B2 Organic light-emitting device SAMSUNG DISPLAY CO., LTD. (KR) 2013-06-04 US disclosed
US-8405074-B2 2013-03-26 US disclosed
US-8405074-B2 2013-03-26 US disclosed
EP-2447250-A1 Organic light-emitting device Samsung Mobile Display Co., Ltd. (KR) 2012-05-02 EP disclosed
US-20120097924-A1 ORGANIC LIGHT-EMITTING DEVICE SAMSUNG MOBILE DISPLAY CO., LTD. (KR) 2012-04-26 US disclosed
US-20120097924-A1 ORGANIC LIGHT-EMITTING DEVICE SAMSUNG MOBILE DISPLAY CO., LTD. (KR) 2012-04-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120097924-A1 ORGANIC LIGHT-EMITTING DEVICE KCNT1, KCNA1, TRPA1 CDK4 1417/4885CCND1 673/4885TNKS2 3762/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.