Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | GUSB | P08236 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21500047 | 0.79 | NR3C1 (0.34) | ABCB1MAOBMAOAGUSBMEN1 | |
| SCHEMBL14276365 | 0.74 | MAOA (0.32) | ABCB1MAOBMAOAGUSB | |
| SCHEMBL16520402 | 0.74 | ABCB1 (0.38) | ABCB1MAOB | |
| SCHEMBL16520407 | 0.74 | ABCB1 (0.38) | ABCB1MAOB | |
| SCHEMBL16556322 | 0.74 | ABCB1 (0.38) | ABCB1MAOB | |
| SCHEMBL16520403 | 0.74 | ABCB1 (0.38) | ABCB1MAOB | |
| SCHEMBL16520401 | 0.74 | ABCB1 (0.38) | ABCB1MAOB | |
| SCHEMBL24924120 | 0.71 | ABCB1 (0.36) | ABCB1POLB | |
| SCHEMBL4825252 | 0.69 | SGMS2 (0.37) | MAOBMAOAGUSBMEN1KMT2A | |
| SCHEMBL171162 | 0.68 | ABCB1 (0.46) | ABCB1MAOBMAOAGUSBPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038492-A1 | NOVEL SUBSTITUTED AMINO-, IMINO-1,2,4 TRIAZINE DERIVATIVES | UNIVERSITÄT HAMBURG (DE) | 2012-03-29 | — | — | WO | disclosed |
| EP-2172457-A2 | Fredericamycin derivatives | Biofrontera Discovery Gmbh (DE) | 2010-04-07 | — | — | EP | disclosed |
| EP-1519724-B1 | FREDERICAMYCIN DERIVATIVES AS MEDICAMENTS FOR TREATING TUMOURS | ZENTOPHARM GMBH (DE) | 2009-09-09 | — | — | EP | disclosed |
| EP-1503988-B1 | FREDERICAMYCIN DERIVATIVES | BIOFRONTERA DISCOVERY GMBH (DE) | 2009-07-22 | — | — | EP | disclosed |
| EP-1495003-B1 | FREDERICAMYCIN DERIVATIVES | BIOFRONTERA DISCOVERY GMBH (DE) | 2008-09-17 | — | — | EP | disclosed |
| WO-2008034895-A2 | ANSAMYCIN DERIVATIVES | DISCOVERY PARTNERS INTERNATIONAL GMBH (DE) | 2008-03-27 | — | — | WO | disclosed |
| WO-2007025534-A1 | FREDERICAMYCIN DERIVATIVES | BIOAGENCY AG (DE) | 2007-03-08 | — | — | WO | disclosed |