SCHEMBL10036591

SCHEMBL10036591

Nc1cc(C(O)(C(F)(F)F)C(F)(F)F)c(N)cc1C(O)(C(F)(F)F)C(F)(F)F

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.61
MEN1 O00255 3/20 0.48
KMT2A Q03164 3/20 0.48
KDM4E B2RXH2 2/20 0.48
MAPT P10636 2/20 0.48
MAPK1 P28482 2/20 0.48
LMNA P02545 1/20 0.48
HTT P42858 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
HSD17B10 Q99714 2/20 0.42
GLA P06280 2/20 0.42
POLB P06746 2/20 0.42
GAA P10253 2/20 0.42
ALDH1A1 P00352 1/20 0.42
HPGD P15428 1/20 0.42
ATM Q13315 1/20 0.42
TSHR P16473 2/20 0.38
ALOX15 P16050 1/20 0.38
AR P10275 3/20 0.34
CA12 O43570 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12128582 0.92 SMN1; SMN2 (0.59) SMN1; SMN2MEN1KMT2AKDM4EMAPT
SCHEMBL14040121 0.89 SMN1; SMN2 (0.52) SMN1; SMN2MEN1KMT2AKDM4EMAPT
SCHEMBL12128351 0.88 SMN1; SMN2 (0.55) SMN1; SMN2MEN1KMT2AKDM4EMAPT
SCHEMBL2782855 0.88 SMN1; SMN2 (0.55) SMN1; SMN2MEN1KMT2AKDM4EMAPT
SCHEMBL12126474 0.87 SMN1; SMN2 (0.55) SMN1; SMN2MEN1KMT2AKDM4EMAPT
SCHEMBL12376375 0.86 SMN1; SMN2 (0.53) SMN1; SMN2MEN1KMT2AKDM4EMAPT
SCHEMBL2785728 0.86 SMN1; SMN2 (0.53) SMN1; SMN2MEN1KMT2AKDM4EMAPT
SCHEMBL2783727 0.86 SMN1; SMN2 (0.53) SMN1; SMN2MEN1KMT2AKDM4EMAPT
SCHEMBL2784763 0.86 SMN1; SMN2 (0.53) SMN1; SMN2MEN1KMT2AKDM4EMAPT
SCHEMBL2784224 0.86 SMN1; SMN2 (0.53) SMN1; SMN2MEN1KMT2AKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021065540-A1 PHOTOSENSITIVE RESIN COMPOSITION, DRY FILM, CURED OBJECT, AND ELECTRONIC COMPONENT 太陽ホールディングス株式会社 2021-04-08 WO disclosed
US-10384172-B2 Composite membrane with multi-layered active layer INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2019-08-20 US disclosed
US-10293308-B2 Antifouling and antimicrobial coatings for thin film composite membranes INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2019-05-21 US disclosed
US-20190015789-A1 ANTIFOULING AND ANTIMICROBIAL COATINGS FOR THIN FILM COMPOSITE MEMBRANES INTERNATIONAL BUSINESS MACHINES CORPORATION 2019-01-17 US disclosed
US-20170144113-A1 COMPOSITE MEMBRANE WITH MULTI-LAYERED ACTIVE LAYER INTERNATIONAL BUSINESS MACHINES CORPORATION 2017-05-25 US disclosed
US-9561474-B2 Composite membrane with multi-layered active layer INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2017-02-07 US disclosed
US-20170001151-A1 ANTIFOULING AND ANTIMICROBIAL COATINGS FOR THIN FILM COMPOSITE MEMBRANES INTERNATIONAL BUSINESS MACHINES CORPORATION 2017-01-05 US disclosed
US-9504967-B2 Composite membrane with multi-layered active layer GLOBALFOUNDRIES INC. (KY) 2016-11-29 US disclosed
EP-2398840-B1 INTERFACIAL POLYMERIZATION METHODS FOR MAKING FLUOROALCOHOL-CONTAINING POLYAMIDES IBM (US) 2016-07-13 EP disclosed
US-20140353253-A1 COMPOSITE MEMBRANE WITH MULTI-LAYERED ACTIVE LAYER GLOBALFOUNDRIES U.S. INC. 2014-12-04 US disclosed
US-20100216899-A1 POLYAMIDE MEMBRANES WITH FLUOROALCOHOL FUNCTIONALITY INTERNATIONAL BUSINESS MACHINES CORPORATION 2010-08-26 US disclosed
US-20100216899-A1 POLYAMIDE MEMBRANES WITH FLUOROALCOHOL FUNCTIONALITY INTERNATIONAL BUSINESS MACHINES CORPORATION 2010-08-26 US disclosed
WO-2010095678-A1 FLUORINATED DICARBOXYLIC ACID DERIVATIVE AND POLYMER OBTAINED THEREFROM セントラル硝子株式会社 (JP) 2010-08-26 WO disclosed
WO-2010096565-A1 INTERFACIAL POLYMERIZATION METHODS FOR MAKING FLUOROALCOHOL-CONTAINING POLYAMIDES INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2010-08-26 WO disclosed
WO-2010096563-A1 POLYAMIDE MEMBRANES WITH FLUOROALCOHOL FUNCTIONALITY INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2010-08-26 WO disclosed
US-20100216967-A1 INTERFACIAL POLYMERIZATION METHODS FOR MAKING FLUOROALCOHOL-CONTAINING POLYAMIDES INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2010-08-26 US disclosed
US-20090030173-A1 NOVEL FLUORINE-CONTAINING DICARBOXYLIC ACIDS AND THEIR NOVEL POLYMER COMPOUNDS CENTRAL GLASS COMPANY, LIMITED (JP) 2009-01-29 US disclosed
US-20090030173-A1 NOVEL FLUORINE-CONTAINING DICARBOXYLIC ACIDS AND THEIR NOVEL POLYMER COMPOUNDS CENTRAL GLASS COMPANY, LIMITED (JP) 2009-01-29 US disclosed
US-20090023886-A1 Waterproofing; oil repellents; heat resistance; weatherproofing; corrosion resistance; radiation transparent; photosensitivity; low refractive index, dielectrics CENTRAL GLASS COMPANY, LIMITED (JP) 2009-01-22 US disclosed
US-20090023886-A1 Waterproofing; oil repellents; heat resistance; weatherproofing; corrosion resistance; radiation transparent; photosensitivity; low refractive index, dielectrics CENTRAL GLASS COMPANY, LIMITED (JP) 2009-01-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090023886-A1 Waterproofing; oil repellents; heat resistance; weatherproofing; corrosion resistance; radiation transparent; photosensitivity; low refractive index, dielectrics PFN1, PFAS, FRG1 SMN1; SMN2 4168/4885MEN1 878/4885KMT2A 3027/4885
US-20090030173-A1 NOVEL FLUORINE-CONTAINING DICARBOXYLIC ACIDS AND THEIR NOVEL POLYMER COMPOUNDS AFF1, ODC1, DDC SMN1; SMN2 2624/4885MEN1 132/4885KMT2A 1603/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.