SCHEMBL10036673

SCHEMBL10036673

CC(C)(c1ccc(N)c(C(O)(C(F)(F)F)C(F)(F)F)c1)c1ccc(N)c(C(O)(C(F)(F)F)C(F)(F)F)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.64
MEN1 O00255 4/20 0.47
KMT2A Q03164 4/20 0.47
MAPK1 P28482 2/20 0.47
HSD17B10 Q99714 2/20 0.47
ALOX15 P16050 1/20 0.47
TSHR P16473 1/20 0.47
MAPT P10636 3/20 0.41
KDM4E B2RXH2 2/20 0.41
LMNA P02545 1/20 0.41
HTT P42858 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
AR P10275 2/20 0.40
NR1H2 P55055 7/20 0.40
NR1H3 Q13133 7/20 0.40
FFAR1 O14842 1/20 0.38
FFAR4 Q5NUL3 1/20 0.38
ESR1 P03372 2/20 0.37
ALDH1A1 P00352 2/20 0.37
GAA P10253 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10036586 0.94 SMN1; SMN2 (0.57) SMN1; SMN2MEN1KMT2AMAPK1HSD17B10
SCHEMBL10002080 0.86 SMN1; SMN2 (0.46) SMN1; SMN2MEN1KMT2AMAPK1HSD17B10
SCHEMBL12128592 0.84 SMN1; SMN2 (0.61) SMN1; SMN2MEN1KMT2AMAPK1HSD17B10
SCHEMBL2754718 0.82 SMN1; SMN2 (0.54) SMN1; SMN2MEN1KMT2AMAPK1HSD17B10
SCHEMBL29937626 0.81 FFAR4 (0.48) SMN1; SMN2MEN1KMT2AHSD17B10TSHR
SCHEMBL7194236 0.81 FFAR4 (0.48) SMN1; SMN2MEN1KMT2AHSD17B10TSHR
SCHEMBL10002088 0.80 SMN1; SMN2 (0.41) SMN1; SMN2MEN1KMT2AMAPK1HSD17B10
SCHEMBL18400646 0.80 ESR1 (0.52) SMN1; SMN2MEN1KMT2AMAPK1HSD17B10
SCHEMBL18400664 0.79 ESR1 (0.50) SMN1; SMN2MEN1KMT2AMAPK1HSD17B10
SCHEMBL10036587 0.78 SMN1; SMN2 (0.54) SMN1; SMN2MEN1KMT2AMAPK1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021065540-A1 PHOTOSENSITIVE RESIN COMPOSITION, DRY FILM, CURED OBJECT, AND ELECTRONIC COMPONENT 太陽ホールディングス株式会社 2021-04-08 WO disclosed
US-10384172-B2 Composite membrane with multi-layered active layer INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2019-08-20 US disclosed
US-10293308-B2 Antifouling and antimicrobial coatings for thin film composite membranes INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2019-05-21 US disclosed
US-20190015789-A1 ANTIFOULING AND ANTIMICROBIAL COATINGS FOR THIN FILM COMPOSITE MEMBRANES INTERNATIONAL BUSINESS MACHINES CORPORATION 2019-01-17 US disclosed
US-20170144113-A1 COMPOSITE MEMBRANE WITH MULTI-LAYERED ACTIVE LAYER INTERNATIONAL BUSINESS MACHINES CORPORATION 2017-05-25 US disclosed
US-9561474-B2 Composite membrane with multi-layered active layer INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2017-02-07 US disclosed
US-20170001151-A1 ANTIFOULING AND ANTIMICROBIAL COATINGS FOR THIN FILM COMPOSITE MEMBRANES INTERNATIONAL BUSINESS MACHINES CORPORATION 2017-01-05 US disclosed
US-9504967-B2 Composite membrane with multi-layered active layer GLOBALFOUNDRIES INC. (KY) 2016-11-29 US disclosed
EP-2398840-B1 INTERFACIAL POLYMERIZATION METHODS FOR MAKING FLUOROALCOHOL-CONTAINING POLYAMIDES IBM (US) 2016-07-13 EP disclosed
US-20140353253-A1 COMPOSITE MEMBRANE WITH MULTI-LAYERED ACTIVE LAYER GLOBALFOUNDRIES U.S. INC. 2014-12-04 US disclosed
US-7728103-B2 Fluorine-containing polymerizable monomer and polymer compound using same CENTRAL GLASS COMPANY, LIMITED (JP) 2010-06-01 US disclosed
US-7728103-B2 Fluorine-containing polymerizable monomer and polymer compound using same CENTRAL GLASS COMPANY, LIMITED (JP) 2010-06-01 US disclosed
US-7629434-B2 Waterproofing; oil repellent; nonabsorber; heat resistance; weatherproofing; corrosion resistance; radiation transparent; photosensitivity; low refractive index and dielectrics CENTRAL GLASS COMPANY, LIMITED (JP) 2009-12-08 US disclosed
US-7629434-B2 Waterproofing; oil repellent; nonabsorber; heat resistance; weatherproofing; corrosion resistance; radiation transparent; photosensitivity; low refractive index and dielectrics CENTRAL GLASS COMPANY, LIMITED (JP) 2009-12-08 US disclosed
US-20090292104-A1 Polyamides from a dianiline compound where one or both of the rings is o-substituted with a 2-hydroxyhexafluoropropyl group and a di- or tetracarboxylic acid; polyimides; polybenzoxazines; repellency, oil repellency, low water absorption; resistance to heat, oil, water, & corrosion; low refractive index CENTRAL GLASS COMPANY, LIMITED (JP) 2009-11-26 US disclosed
US-20090292104-A1 Polyamides from a dianiline compound where one or both of the rings is o-substituted with a 2-hydroxyhexafluoropropyl group and a di- or tetracarboxylic acid; polyimides; polybenzoxazines; repellency, oil repellency, low water absorption; resistance to heat, oil, water, & corrosion; low refractive index CENTRAL GLASS COMPANY, LIMITED (JP) 2009-11-26 US disclosed
US-20090030173-A1 NOVEL FLUORINE-CONTAINING DICARBOXYLIC ACIDS AND THEIR NOVEL POLYMER COMPOUNDS CENTRAL GLASS COMPANY, LIMITED (JP) 2009-01-29 US disclosed
US-20090030173-A1 NOVEL FLUORINE-CONTAINING DICARBOXYLIC ACIDS AND THEIR NOVEL POLYMER COMPOUNDS CENTRAL GLASS COMPANY, LIMITED (JP) 2009-01-29 US disclosed
US-20080234460-A1 Fluorine-Containing Polymerizable Monomer and Polymer Compound Using Same CENTRAL GLASS CO., LTD. (JP) 2008-09-25 US disclosed
US-20080234460-A1 Fluorine-Containing Polymerizable Monomer and Polymer Compound Using Same CENTRAL GLASS CO., LTD. (JP) 2008-09-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080234460-A1 Fluorine-Containing Polymerizable Monomer and Polymer Compound Using Same AFF2, FRG1, PFAS SMN1; SMN2 1644/4885MEN1 1434/4885KMT2A 912/4885
US-20090030173-A1 NOVEL FLUORINE-CONTAINING DICARBOXYLIC ACIDS AND THEIR NOVEL POLYMER COMPOUNDS AFF1, ODC1, DDC SMN1; SMN2 2624/4885MEN1 132/4885KMT2A 1603/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.