Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PHPT1 | Q9NRX4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | S100A4 | P26447 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12405284 | 0.79 | MAPT (0.59) | ALDH1A1MAPTKDM4ECYP3A4CTSB | |
| SCHEMBL12142799 | 0.79 | VCAM1 (0.51) | ALDH1A1MAPK1TSHR | |
| SCHEMBL12715334 | 0.79 | TSHR (0.55) | ALDH1A1MAPTCYP3A4LMNAMEN1 | |
| SCHEMBL6124791 | 0.79 | MAPT (0.58) | ALDH1A1MAPTCYP3A4LMNAMEN1 | |
| SCHEMBL12625747 | 0.79 | ALDH1A1 (0.56) | ALDH1A1MAPTLMNAMEN1MAPK1 | |
| SCHEMBL29953181 | 0.79 | TSHR (0.55) | ALDH1A1MAPTCYP3A4LMNAMEN1 | |
| SCHEMBL12619129 | 0.78 | ALDH1A1 (0.45) | ALDH1A1MAPTKDM4ECYP3A4MAPK1 | |
| SCHEMBL12138529 | 0.78 | ALDH1A1 (0.58) | ALDH1A1CYP2D6MAPTKDM4ECYP3A4 | |
| SCHEMBL12715337 | 0.76 | MAPT (0.51) | ALDH1A1MAPTKDM4ECYP3A4MEN1 | |
| SCHEMBL12857986 | 0.76 | GPR35 (0.56) | ALDH1A1MAPTKDM4ECYP3A4CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8487104-B2 | KAT II inhibitors | PFIZER INC. (US) | 2013-07-16 | — | — | US | disclosed |
| US-20120142729-A1 | KAT ll INHIBITORS | PFIZER INC. | 2012-06-07 | — | — | US | disclosed |
| US-7951827-B2 | Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2011-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142729-A1 | KAT ll INHIBITORS | KAT7, KAT2A, KATNA1 | ALDH1A1 2408/4885CYP2D6 2754/4885MAPT 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.