Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19382446 | 0.86 | SIGMAR1 (0.44) | SIGMAR1ALDH1A1NPSR1LMNAHTT | |
| SCHEMBL15854539 | 0.83 | LMNA (0.42) | SIGMAR1ALDH1A1NPSR1LMNAHTT | |
| SCHEMBL10407959 | 0.80 | SIGMAR1 (0.40) | SIGMAR1ALDH1A1NPSR1LMNAHTT | |
| SCHEMBL17018034 | 0.80 | MAPT (0.43) | SIGMAR1ALDH1A1NPSR1LMNAHTT | |
| SCHEMBL10037099 | 0.78 | RAPGEF4 (0.52) | ALDH1A1LMNAHTTSMN1; SMN2MEN1 | |
| SCHEMBL29673248 | 0.78 | AAK1 (0.43) | ALDH1A1LMNAHTTSMN1; SMN2MEN1 | |
| SCHEMBL9102892 | 0.78 | AAK1 (0.43) | ALDH1A1LMNAHTTSMN1; SMN2MEN1 | |
| SCHEMBL10408259 | 0.78 | GABRA1 (0.42) | ALDH1A1LMNAHTTSMN1; SMN2MEN1 | |
| SCHEMBL741149 | 0.78 | KDM4E (0.46) | ALDH1A1LMNAHTTSMN1; SMN2HPGD | |
| SCHEMBL4611466 | 0.76 | SIGMAR1 (0.49) | SIGMAR1ALDH1A1NPSR1HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022070-A1 | Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use | EMORY UNIVERSITY (US) | 2012-01-26 | — | — | US | disclosed |
| US-4925984-A | REACTION WITH BROMINE IN SOLUTION | ETHYL CORPORATION (US) | 1990-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022070-A1 | Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use | HSP90AB1, HSP90AA1, HSP90AB2P | SIGMAR1 3928/4885ALDH1A1 2606/4885NPSR1 4378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.