Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.77 |
| ▸ | NSD2 | O96028 | 3/20 | 0.71 |
| ▸ | HKDC1 | Q2TB90 | 3/20 | 0.71 |
| ▸ | APAF1 | O14727 | 2/20 | 0.71 |
| ▸ | TDP2 | O95551 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | GALK1 | P51570 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.67 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.67 |
| ▸ | HTR7 | P34969 | 3/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR5A | P47898 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL246623 | 0.88 | DNMT1 (0.59) | DNMT1NSD2HKDC1APAF1TDP2 | |
| SCHEMBL7260223 | 0.83 | APAF1 (1.00) | DNMT1NSD2HKDC1APAF1TDP2 | |
| SCHEMBL30601628 | 0.80 | APAF1 (1.00) | DNMT1NSD2HKDC1APAF1TDP2 | |
| SCHEMBL4649553 | 0.80 | DNMT1 (0.83) | DNMT1NSD2HKDC1APAF1TDP2 | |
| SCHEMBL4647391 | 0.80 | APAF1 (1.00) | DNMT1NSD2HKDC1APAF1TDP2 | |
| SCHEMBL4876610 | 0.72 | APAF1 (0.74) | DNMT1NSD2HKDC1APAF1TDP2 | |
| SCHEMBL31290245 | 0.72 | APAF1 (0.74) | DNMT1NSD2HKDC1APAF1TDP2 | |
| SCHEMBL10556309 | 0.71 | HTR7 (0.50) | NSD2APAF1TDP2MEN1NPC1 | |
| SCHEMBL249168 | 0.70 | APAF1 (0.77) | DNMT1NSD2HKDC1APAF1TDP2 | |
| SCHEMBL31290115 | 0.70 | APAF1 (0.77) | DNMT1NSD2HKDC1APAF1TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022070-A1 | Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use | EMORY UNIVERSITY (US) | 2012-01-26 | — | — | US | disclosed |
| US-20120022070-A1 | Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use | EMORY UNIVERSITY (US) | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022070-A1 | Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use | HSP90AB1, HSP90AA1, HSP90AB2P | DNMT1 4257/4885NSD2 4199/4885HKDC1 3871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.