Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.35 |
| ▸ | MDM4 | O15151 | 5/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 5/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.31 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8272139 | 0.78 | ACHE (0.39) | HSD11B1MDM4MDM2OPRM1ALDH1A1 | |
| SCHEMBL1001744 | 0.78 | ACHE (0.39) | HSD11B1MDM4MDM2OPRM1ALDH1A1 | |
| SCHEMBL12413553 | 0.78 | HSD11B1 (0.37) | HSD11B1MDM4MDM2GRIN2DGRIN3B | |
| SCHEMBL1054185 | 0.76 | MEN1 (0.44) | AMY1AALDH1A1KDM4E | |
| SCHEMBL27703849 | 0.71 | AMY1A (0.34) | AMY1AMDM4MDM2HDAC8 | |
| SCHEMBL8239554 | 0.71 | PIK3CG (0.39) | AMY1AHSD11B1OPRM1POLB | |
| SCHEMBL2026452 | 0.70 | PIK3CG (0.40) | HSD11B1OPRM1HDAC1HDAC6 | |
| SCHEMBL2025196 | 0.70 | PIK3CG (0.40) | HSD11B1OPRM1HDAC1HDAC6 | |
| SCHEMBL2024709 | 0.70 | PIK3CG (0.43) | HSD11B1HDAC1HDAC6 | |
| SCHEMBL2024712 | 0.70 | PIK3CG (0.43) | HSD11B1HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2357169-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | AstraZeneca AB (SE) | 2011-08-17 | — | — | EP | disclosed |
| US-20110166155-A1 | Substituted Isoindolones and Their Use as Metabotropic Glutamate Receptor Potentiators | VAN WAGENEN BRADFORD | 2011-07-07 | — | — | US | disclosed |
| US-7868008-B2 | Substituted isoindolones and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2011-01-11 | — | — | US | disclosed |
| US-20090111830-A1 | SUBSTITUTED ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2009-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111830-A1 | SUBSTITUTED ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | GRM1, GRIN1, GRM2 | AMY1A 4876/4885HSD11B1 3234/4885MDM4 4410/4885 |
| US-20110166155-A1 | Substituted Isoindolones and Their Use as Metabotropic Glutamate Receptor Potentiators | GRM1, GRIN1, GRM2 | AMY1A 4876/4885HSD11B1 3234/4885MDM4 4410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.