SCHEMBL10041437

SCHEMBL10041437

COC1OC(CO)C(C)C(OC(C)=O)C1O

nearest known ligand 0.56

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ LGALS8 O00214 8/20 0.56
▸ CD69 Q07108 1/20 0.40
▸ PTPN1 P18031 1/20 0.38
▸ FGF1 P05230 1/20 0.37
▸ LGALS3 P17931 3/20 0.37
▸ LGALS9 O00182 1/20 0.36
▸ CYP2D6 P10635 1/20 0.36
▸ THRB P10828 1/20 0.36
▸ HSD17B10 Q99714 1/20 0.36
▸ MGAM O43451 1/20 0.35
▸ SI P14410 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26878914 0.88 LGALS8 (0.46) LGALS8CYP2D6THRBHSD17B10
SCHEMBL13658762 0.88 LGALS8 (0.49) LGALS8CD69PTPN1FGF1LGALS3
SCHEMBL29220914 0.88 LGALS8 (0.71) LGALS8CD69PTPN1LGALS3LGALS9
SCHEMBL13419004 0.88 LGALS8 (0.44) LGALS8CD69FGF1LGALS3LGALS9
SCHEMBL12410177 0.88 LGALS8 (0.44) LGALS8CD69FGF1LGALS3LGALS9
SCHEMBL15498430 0.87 LGALS8 (0.62) LGALS8FGF1LGALS3THRB
SCHEMBL13419006 0.85 CYP2D6 (0.49) LGALS8CYP2D6THRBHSD17B10
SCHEMBL12410178 0.85 CYP2D6 (0.49) LGALS8CYP2D6THRBHSD17B10
SCHEMBL13658767 0.84 LGALS8 (0.44) LGALS8CD69FGF1LGALS9CYP2D6
SCHEMBL16327733 0.83 LGALS8 (0.60) LGALS8CD69PTPN1FGF1LGALS3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9387252-B2 Pharmaceutical compositions with enhanced performance BEND RESEARCH, INC. (US) 2016-07-12 — — US disclosed
US-9040033-B2 Hydroxypropyl methyl cellulose acetate succinate with enhanced acetate and succinate substitution DOW GLOBAL TECHNOLOGIES LLC 2015-05-26 — — US disclosed
US-8940800-B2 Pharmaceutical compositions with enhanced performance BEND RESEARCH, INC. (US) 2015-01-27 — — US disclosed
US-20130102691-A1 HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE WITH ENHANCED ACETATE AND SUCCINATE SUBSTITUTION DOW GLOBAL TECHNOLOGIES LLC (US) 2013-04-25 — — US disclosed
US-20120264833-A1 PHARMACEUTICAL COMPOSITIONS WITH ENHANCED PERFORMANCE LONZA BEND INC. 2012-10-18 — — US disclosed
US-8207232-B2 Pharmaceutical compositions with enhanced performance BEND RESEARCH, INC. (US) 2012-06-26 — — US disclosed
US-20080262107-A1 A solid amorphous dispersion of a low-soluble drug and hydroxypropylmethyl celllulose acetate succinate with an ester degree of substitution of 0.85 which results in concentration-enhancement, time release agents, and storage stability; rapid crystal growth inhibitors in supersaturated aqueous solutions PFIZER PRODUCTS INC. (US) 2008-10-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130102691-A1 HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE WITH ENHANCED ACETATE AND SUCCINATE SUBSTITUTION HPD, CS, PCCA LGALS8 2357/4885CD69 2925/4885PTPN1 3583/4885
US-20080262107-A1 A solid amorphous dispersion of a low-soluble drug and hydroxypropylmethyl celllulose acetate succinate with an ester degree of substitution of 0.85 which results in concentration-enhancement, time release agents, and storage stability; rapid crystal growth inhibitors in supersaturated aqueous solutions HPD, HAAO, SUCLA2 LGALS8 2915/4885CD69 861/4885PTPN1 3174/4885
US-20120264833-A1 PHARMACEUTICAL COMPOSITIONS WITH ENHANCED PERFORMANCE HPD, HAAO, MCCC2 LGALS8 1999/4885CD69 3071/4885PTPN1 2732/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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