Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.58 |
| ▸ | F13A1 | P00488 | 2/20 | 0.57 |
| ▸ | TGM2 | P21980 | 2/20 | 0.57 |
| ▸ | TGM1 | P22735 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10042199 | 0.88 | EPHX2 (0.53) | TDP1EPHX2F13A1TGM2TGM1 | |
| SCHEMBL308426 | 0.85 | TGM2 (0.53) | TDP1EPHX2F13A1TGM2TGM1 | |
| SCHEMBL18410584 | 0.83 | TGM2 (0.65) | F13A1TGM2TGM1ALDH1A1POLB | |
| SCHEMBL10042197 | 0.81 | TDP1 (0.55) | TDP1EPHX2F13A1TGM2TGM1 | |
| SCHEMBL2226727 | 0.80 | TGM2 (0.64) | EPHX2F13A1TGM2TGM1RAB9A | |
| SCHEMBL5301558 | 0.79 | TGM2 (0.55) | F13A1TGM2TGM1ALDH1A1POLB | |
| SCHEMBL11945569 | 0.79 | TGM2 (0.49) | EPHX2F13A1TGM2TGM1POLB | |
| SCHEMBL1955697 | 0.79 | ALDH1A1 (0.62) | F13A1TGM2TGM1ALDH1A1POLB | |
| SCHEMBL16771434 | 0.79 | BRD4 (0.69) | F13A1TGM2TGM1POLB | |
| SCHEMBL698155 | 0.78 | EPHX2 (0.46) | TDP1EPHX2F13A1TGM2TGM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8536183-B2 | 3-pyridylcarbonyl-piperazinylsulfonyl derivatives | Convergence Pharmaceuticals Limited (GB) | 2013-09-17 | — | — | US | disclosed |
| US-20120302746-A1 | 3-PYRIDYLCARBONYL-PIPERAZINYLSULFONYL DERIVATIVES | BESWICK PAUL JOHN (GB) | 2012-11-29 | — | — | US | disclosed |
| US-8288388-B2 | 3-pyridylcarbonyl-piperazinylsulfonyl derivatives | Convergence Pharmaceuticals Limited (GB) | 2012-10-16 | — | — | US | disclosed |
| US-8093249-B2 | Pyrazolo[1,5-A]pyrimidine-carbonyl-piperazine derivatives | Convergence Pharmaceuticals Limited (GB) | 2012-01-10 | — | — | US | disclosed |
| US-20100022555-A1 | Novel Derivatives | Convergence Pharmaceuticals Limited (GB) | 2010-01-28 | — | — | US | disclosed |
| US-20100016330-A1 | Novel Derivatives | Convergence Pharmaceuticals Limited (GB) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016330-A1 | Novel Derivatives | CACNB2, CACNA1B, CACNA1D | TDP1 4090/4885EPHX2 3915/4885F13A1 4570/4885 |
| US-20100022555-A1 | Novel Derivatives | CACNB2, CACNA1B, CACNA1D | TDP1 4090/4885EPHX2 3915/4885F13A1 4570/4885 |
| US-20120302746-A1 | 3-PYRIDYLCARBONYL-PIPERAZINYLSULFONYL DERIVATIVES | CACNB2, CACNA1C, KCNJ2 | TDP1 4313/4885EPHX2 4441/4885F13A1 4492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.