SCHEMBL1004258

SCHEMBL1004258

COC(=O)CCn1c2ccccc2c2ccccc21

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FABP4 P15090 3/20 0.64
FABP5 Q01469 3/20 0.64
FABP3 P05413 1/20 0.64
FNTA P49354 1/20 0.63
FNTB P49356 1/20 0.63
HDAC6 Q9UBN7 4/20 0.63
KDM4E B2RXH2 3/20 0.62
CTNNB1 P35222 1/20 0.59
CNR2 P34972 3/20 0.54
HDAC1 Q13547 3/20 0.54
CNR1 P21554 1/20 0.53
ALDH1A1 P00352 2/20 0.52
MAPT P10636 1/20 0.52
HPGD P15428 1/20 0.52
TSHR P16473 1/20 0.52
CYP1A2 P05177 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2C19 P33261 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31367787 1.00 FABP4 (0.64) FABP4FABP5FABP3FNTAFNTB
SCHEMBL14160820 0.92 CTNNB1 (0.55) FABP4FABP5FABP3FNTAFNTB
SCHEMBL1002948 0.89 FABP4 (0.67) FABP4FABP5FABP3FNTAFNTB
SCHEMBL13301256 0.87 ACHE (0.52) FABP4FABP5FABP3FNTAFNTB
SCHEMBL11823172 0.87 MAPT (0.57) FABP4FABP5FABP3FNTAFNTB
SCHEMBL11604659 0.86 ALDH1A1 (0.71) FABP4FABP5FABP3FNTAFNTB
SCHEMBL11821506 0.84 MAPT (0.69) FABP4FABP5FABP3FNTAFNTB
SCHEMBL1128275 0.83 FNTA (0.68) FABP4FABP5FABP3FNTAFNTB
SCHEMBL29937494 0.82 F10 (0.53) FABP4FABP5FABP3FNTAFNTB
SCHEMBL3202252 0.82 KDM4E (0.69) KDM4EALDH1A1MAPTHPGDTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3625316-B1 DISPERSANTS, METHOD OF MAKING, AND USING SAME CHEVRON ORONITE CO (US) 2023-08-23 EP disclosed
CN-110621766-B Dispersant, method of manufacture and use thereof 雪佛龙奥伦耐有限责任公司 2021-12-24 CN disclosed
US-10815446-B2 Dispersants, method of making, and using same CHEVRON ORONITE COMPANY LLC (US) 2020-10-27 US disclosed
EP-3625316-A1 DISPERSANTS, METHOD OF MAKING, AND USING SAME Chevron Oronite Company LLC (US) 2020-03-25 EP disclosed
CN-110621766-A Dispersant, method of manufacture and use thereof 雪佛龙奥伦耐有限责任公司 2019-12-27 CN disclosed
EP-2456757-B1 HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME UNIV ILLINOIS (US) 2019-05-01 EP disclosed
EP-2456757-B1 HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME UNIV ILLINOIS (US) 2019-05-01 EP disclosed
US-20180334635-A1 DISPERSANTS, METHOD OF MAKING, AND USING SAME CHEVRON ORONITE COMPANY LLC 2018-11-22 US disclosed
WO-2018211466-A1 DISPERSANTS, METHOD OF MAKING, AND USING SAME CHEVRON ORONITE COMPANY LLC (US) 2018-11-22 WO disclosed
US-8748451-B2 HDAC inhibitors and therapeutic methods of using same THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2014-06-10 US disclosed
US-8431538-B2 HDAC inhibitors and therapeutic methods of using same THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2013-04-30 US disclosed
US-8431538-B2 HDAC inhibitors and therapeutic methods of using same THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2013-04-30 US disclosed
US-20120252740-A1 HDAC INHIBITORS AND THERAPEUTIC METHODS OF USING SAME KOZIKOWSKI ALAN (US) 2012-10-04 US disclosed
US-20120252740-A1 HDAC INHIBITORS AND THERAPEUTIC METHODS OF USING SAME KOZIKOWSKI ALAN (US) 2012-10-04 US disclosed
US-20120252740-A1 HDAC INHIBITORS AND THERAPEUTIC METHODS OF USING SAME KOZIKOWSKI ALAN (US) 2012-10-04 US disclosed
EP-2456757-A2 HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME The Board of Trustees of the University of Illinois (US) 2012-05-30 EP disclosed
WO-2011011186-A2 HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2011-01-27 WO disclosed
WO-2011011186-A2 HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2011-01-27 WO disclosed
US-3988208-A FOR GLUCOSE BOEHRINGER MANNHEIM G.M.B.H. (DT) 1976-10-26 US disclosed
US-3975398-A INDICATOR FOR DETERMINATION OF GLUCOSE BOEHRINGER MANNHEIM G.M.B.H. (DT) 1976-08-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120252740-A1 HDAC INHIBITORS AND THERAPEUTIC METHODS OF USING SAME HDAC1, HDAC9, HDAC5 FABP4 3757/4885FABP5 2195/4885FABP3 1670/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.