Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.78 |
| ▸ | GAA | P10253 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PRNP | P04156 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5209174 | 0.84 | ALDH1A1 (0.58) | ALDH1A1CYP1A2CYP2C19GAAL3MBTL1 | |
| SCHEMBL17538707 | 0.83 | ALDH1A1 (0.67) | ALDH1A1CYP1A2CYP2C19GAAL3MBTL1 | |
| SCHEMBL5960627 | 0.83 | ALDH1A1 (0.56) | ALDH1A1CYP1A2CYP2C19GAAL3MBTL1 | |
| SCHEMBL7028752 | 0.82 | ALDH1A1 (0.58) | ALDH1A1CYP1A2CYP2C19GAAL3MBTL1 | |
| SCHEMBL29122979 | 0.82 | ALDH1A1 (0.62) | ALDH1A1CYP1A2CYP2C19GAAL3MBTL1 | |
| SCHEMBL4266082 | 0.82 | ALDH1A1 (0.58) | ALDH1A1CYP1A2CYP2C19GAAL3MBTL1 | |
| SCHEMBL5106323 | 0.82 | ALDH1A1 (0.65) | ALDH1A1CYP1A2CYP2C19GAAL3MBTL1 | |
| SCHEMBL1327130 | 0.81 | ALDH1A1 (0.53) | ALDH1A1CYP1A2CYP2C19GAAL3MBTL1 | |
| SCHEMBL16784831 | 0.81 | ALDH1A1 (0.57) | ALDH1A1CYP1A2CYP2C19GAAL3MBTL1 | |
| SCHEMBL1326587 | 0.80 | ALDH1A1 (0.53) | ALDH1A1CYP1A2CYP2C19GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633245-B2 | PAI-1 inhibitor | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2014-01-21 | — | — | US | disclosed |
| EP-2272817-A1 | PAI-1 INHIBITOR | Institute of Medicinal Molecular Design, Inc. (JP) | 2011-01-12 | — | — | EP | disclosed |
| US-20090312315-A1 | PAI-1 INHIBITOR | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312315-A1 | PAI-1 INHIBITOR | SERPINC1, SERPINE1, SERPINH1 | ALDH1A1 1168/4885CYP1A2 1158/4885CYP2C19 1903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.