Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CBLB | Q13191 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12124216 | 0.93 | ALDH1A1 (0.50) | ALDH1A1CYP1A2CYP2C19GAAL3MBTL1 | |
| SCHEMBL7843179 | 0.89 | ALDH1A1 (0.67) | ALDH1A1CYP1A2CYP2C19GAAL3MBTL1 | |
| SCHEMBL13215569 | 0.89 | ALDH1A1 (0.46) | ALDH1A1CYP1A2CYP2C19GAAL3MBTL1 | |
| SCHEMBL2059346 | 0.84 | MAPT (0.49) | ALDH1A1CYP1A2CYP2C19GAAMAPT | |
| SCHEMBL21070030 | 0.84 | ALDH1A1 (0.46) | ALDH1A1CYP1A2CYP2C19MAPTKMT2A | |
| SCHEMBL20042055 | 0.84 | ALDH1A1 (0.55) | ALDH1A1CYP1A2CYP2C19MAPTKMT2A | |
| SCHEMBL3536740 | 0.84 | ALDH1A1 (0.60) | ALDH1A1CYP1A2CYP2C19MAPTKMT2A | |
| SCHEMBL4072031 | 0.82 | KDM4E (0.51) | ALDH1A1GAAL3MBTL1MAPTKMT2A | |
| SCHEMBL7513156 | 0.82 | HTT (0.50) | ALDH1A1MAPTKMT2AMEN1LMNA | |
| SCHEMBL12776980 | 0.81 | ALDH1A1 (0.49) | ALDH1A1GAAMAPTKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498607-B1 | KINASE INHIBITORS | GENOSCO (US) | 2016-02-17 | — | — | EP | disclosed |
| US-8629132-B2 | Kinase inhibitors | GENOSCO (US) | 2014-01-14 | — | — | US | disclosed |
| US-8629132-B2 | Kinase inhibitors | GENOSCO (US) | 2014-01-14 | — | — | US | disclosed |
| EP-2498607-A1 | KINASE INHIBITORS | Genosco (US) | 2012-09-19 | — | — | EP | disclosed |
| US-8211900-B2 | DHFR enzyme inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2012-07-03 | — | — | US | disclosed |
| US-8211900-B2 | DHFR enzyme inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2012-07-03 | — | — | US | disclosed |
| US-20110281841-A1 | Kinase Inhibitors | OSCOTEC, INC. (KR) | 2011-11-17 | — | — | US | disclosed |
| US-20110281841-A1 | Kinase Inhibitors | OSCOTEC, INC. (KR) | 2011-11-17 | — | — | US | disclosed |
| WO-2011060295-A1 | KINASE INHIBITORS | GENOSCO (US) | 2011-05-19 | — | — | WO | disclosed |
| US-20090118311-A1 | DHFR Enzyme Inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2009-05-07 | — | — | US | disclosed |
| US-20090118311-A1 | DHFR Enzyme Inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2009-05-07 | — | — | US | disclosed |
| WO-2007132146-A1 | DHFR ENZYME INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2007-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118311-A1 | DHFR Enzyme Inhibitors | DHFR, MTHFD1, ALDH7A1 | ALDH1A1 216/4885CYP1A2 253/4885CYP2C19 750/4885 |
| US-20110281841-A1 | Kinase Inhibitors | LCK, PDK1, MAP3K11 | ALDH1A1 2587/4885CYP1A2 3381/4885CYP2C19 2475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.