Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 11/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2193998 | 1.00 | CYP19A1 (1.00) | CYP19A1HDAC1HSP90AB1HRH4MAOA | |
| SCHEMBL28533317 | 0.98 | CYP19A1 (0.97) | CYP19A1HDAC1HSP90AB1HRH4MAOA | |
| SCHEMBL16206208 | 0.91 | CYP19A1 (0.82) | CYP19A1HDAC1HSP90AB1HRH4MAOA | |
| SCHEMBL2641384 | 0.88 | CYP19A1 (1.00) | CYP19A1HDAC1HSP90AB1HRH4MAOA | |
| SCHEMBL2194279 | 0.88 | CYP19A1 (0.77) | CYP19A1HDAC1HSP90AB1HRH4MAOA | |
| SCHEMBL15795903 | 0.85 | CYP19A1 (0.74) | CYP19A1HDAC1HSP90AB1HRH4MAOA | |
| SCHEMBL15796292 | 0.84 | CYP19A1 (0.72) | CYP19A1HDAC1HSP90AB1HRH4MAOA | |
| SCHEMBL15836589 | 0.84 | CYP19A1 (0.72) | CYP19A1HDAC1HSP90AB1HRH4MAOA | |
| SCHEMBL30657567 | 0.84 | CYP19A1 (0.72) | CYP19A1HDAC1HSP90AB1HRH4MAOA | |
| SCHEMBL28220729 | 0.82 | CYP19A1 (0.70) | CYP19A1HDAC1HSP90AB1HRH4MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507769-B2 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | SCRIPPS RESEARCH INST (US) | 2017-10-11 | — | — | EP | disclosed |
| US-20160214946-A1 | CATALYSED LIGATION OF AZIDES AND ACETYLENES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-07-28 | — | — | US | disclosed |
| US-9302997-B2 | Copper-catalysed ligation of azides and acetylenes | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-04-05 | — | — | US | disclosed |
| EP-2226316-B1 | Copper-catalysed ligation of azides and acetylenes | SCRIPPS RESEARCH INST (US) | 2016-01-13 | — | — | EP | disclosed |
| US-20150232432-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-08-20 | — | — | US | disclosed |
| US-9040716-B2 | Copper-catalysed ligation of azides and acetylenes | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-05-26 | — | — | US | disclosed |
| US-20150031895-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-01-29 | — | — | US | disclosed |
| US-8877939-B2 | Copper-catalysed ligation of azides and acetylenes | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-11-04 | — | — | US | disclosed |
| US-20140066632-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-03-06 | — | — | US | disclosed |
| US-8580970-B2 | Copper-catalysed ligation of azides and acetylenes | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-11-12 | — | — | US | disclosed |
| US-20120165542-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-06-28 | — | — | US | disclosed |
| EP-2226316-A1 | Copper-catalysed ligation of azides and acetylenes | The Scripps Research Institute (US) | 2010-09-08 | — | — | EP | disclosed |
| EP-1507769-B1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | SCRIPPS RESEARCH INST (US) | 2010-05-26 | — | — | EP | disclosed |
| US-7375234-B2 | regiospecifically ligates azides and terminal acetylenes to give only 1,4-disubstituted [1,2,3]-triazoles; stepwise Huisgen cycloaddition process catalyzed by copper | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150232432-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | SOD1, AOC3, AOC2 | CYP19A1 1934/4885HDAC1 584/4885HSP90AB1 4428/4885 |
| US-20120165542-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | AOC3, ADH1C, AOC2 | CYP19A1 2969/4885HDAC1 875/4885HSP90AB1 2943/4885 |
| US-20160214946-A1 | CATALYSED LIGATION OF AZIDES AND ACETYLENES | AOC3, AOC2, KARS1 | CYP19A1 1159/4885HDAC1 658/4885HSP90AB1 4081/4885 |
| US-20150031895-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | AOC3, SOD1, AOC2 | CYP19A1 2247/4885HDAC1 768/4885HSP90AB1 3791/4885 |
| US-20140066632-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | AOC3, SOD1, AOC2 | CYP19A1 2247/4885HDAC1 768/4885HSP90AB1 3791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.