Sugi Predict

Sugi Predict / Compounds / SCHEMBL10046477

SCHEMBL10046477

SCHEMBL10046477

O=C1CC(c2ccccc2)CC2=C1C(c1ccc(O)c(O)c1)C1=C(CC(c3ccccc3)CC1=O)O2

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.46
▸ MAPT P10636 4/20 0.46
▸ HTT P42858 2/20 0.46
▸ POLB P06746 3/20 0.40
▸ KDM4E B2RXH2 3/20 0.40
▸ GAA P10253 3/20 0.40
▸ PPARG P37231 2/20 0.40
▸ ALPI P09923 2/20 0.40
▸ RECQL P46063 2/20 0.40
▸ BLM P54132 1/20 0.40
▸ MCL1 Q07820 1/20 0.40
▸ ATM Q13315 1/20 0.40
▸ MAP1LC3B Q9GZQ8 3/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ CYP19A1 P11511 2/20 0.39
▸ PKM P14618 2/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ NPSR1 Q6W5P4 1/20 0.37
▸ HPGD P15428 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10046482 0.86 GAA (0.51) ALDH1A1MAPTHTTPOLBKDM4E
SCHEMBL15057097 0.80 GAA (0.43) ALDH1A1POLBKDM4EGAAPPARG
SCHEMBL10046491 0.78 TSHR (0.41) ALDH1A1MAPTHTTPOLBKDM4E
SCHEMBL10046494 0.75 GAA (0.56) ALDH1A1MAPTHTTPOLBGAA
SCHEMBL326212 0.74 ALDH1A1 (0.46) ALDH1A1MAPTHTTGAAMAP1LC3B
SCHEMBL15059210 0.72 KDM4E (0.45) ALDH1A1MAPTHTTPOLBKDM4E
SCHEMBL14890298 0.71 MEN1 (0.67) ALDH1A1MAPTHTTKDM4EGAA
SCHEMBL14904060 0.70 GAA (0.51) ALDH1A1MAPTHTTPOLBGAA
SCHEMBL3004220 0.67 ALDH1A1 (0.43) ALDH1A1MAPTHTTGAAMAP1LC3B
SCHEMBL3129599 0.66 ALDH1A1 (0.72) ALDH1A1MAPTHTTPOLBKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8906416-B2 Xanthenedione derivatives for the treatment of pigmentation and skin ageing disorders PIERRE FABRE DERMO-COSMETIQUE (FR) 2014-12-09 — — US disclosed
US-8906416-B2 Xanthenedione derivatives for the treatment of pigmentation and skin ageing disorders PIERRE FABRE DERMO-COSMETIQUE (FR) 2014-12-09 — — US disclosed
US-20130108568-A1 XANTHENEDIONE DERIVATIVES FOR THE TREATMENT OF PIGMENTATION AND SKIN AGEING DISORDERS PIERRE FABRE DERMO-COSMETIQUE (FR) 2013-05-02 — — US disclosed
US-20130108568-A1 XANTHENEDIONE DERIVATIVES FOR THE TREATMENT OF PIGMENTATION AND SKIN AGEING DISORDERS PIERRE FABRE DERMO-COSMETIQUE (FR) 2013-05-02 — — US disclosed
US-20130108568-A1 XANTHENEDIONE DERIVATIVES FOR THE TREATMENT OF PIGMENTATION AND SKIN AGEING DISORDERS PIERRE FABRE DERMO-COSMETIQUE (FR) 2013-05-02 — — US disclosed
WO-2012004390-A1 XANTHENEDIONE DERIVATIVES FOR THE TREATMENT OF PIGMENTATION AND SKIN AGEING DISORDERS PIERRE FABRE DERMO-COSMETIQUE (FR) 2012-01-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130108568-A1 XANTHENEDIONE DERIVATIVES FOR THE TREATMENT OF PIGMENTATION AND SKIN AGEING DISORDERS ACOX3, CBR3, GALR3 ALDH1A1 1099/4885MAPT 3426/4885HTT 987/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.