Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.46 |
| ▸ | NOS3 | P29474 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1754869 | 0.82 | NOS1 (0.51) | NOS2NOS3NOS1POLB | |
| SCHEMBL10047205 | 0.80 | KMT2A (0.43) | NOS2NOS3NOS1LMNAGAA | |
| SCHEMBL18711185 | 0.79 | DRD4 (0.46) | POLBALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL2090954 | 0.73 | MAPT (0.45) | NOS2NOS3NOS1LMNAGAA | |
| SCHEMBL29854102 | 0.70 | DRD4 (0.48) | LMNAALDH1A1CYP1A2KMT2AMEN1 | |
| SCHEMBL3998344 | 0.66 | TSHR (0.42) | LMNAGAAPOLBALDH1A1TSHR | |
| SCHEMBL10047202 | 0.65 | NOS3 (0.39) | NOS2NOS3NOS1LMNAGAA | |
| SCHEMBL18700886 | 0.65 | ACE (0.47) | ALDH1A1 | |
| SCHEMBL11975683 | 0.63 | DPP8 (0.41) | NOS2NOS3NOS1LMNAGAA | |
| SCHEMBL11934336 | 0.63 | OPRD1 (0.41) | POLBALDH1A1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928845-B1 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC (US) | 2013-07-10 | — | — | EP | claimed |
| US-8673898-B2 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-8673898-B2 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC. (US) | 2014-03-18 | — | — | US | disclosed |
| EP-1928845-B1 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC (US) | 2013-07-10 | — | — | EP | disclosed |
| US-20120208801-A1 | Aminodiazepines as Toll-Like Receptor Modulators | ARRAY BIOPHARMA INC. (US) | 2012-08-16 | — | — | US | disclosed |
| US-20120208801-A1 | Aminodiazepines as Toll-Like Receptor Modulators | ARRAY BIOPHARMA INC. (US) | 2012-08-16 | — | — | US | disclosed |
| US-8163738-B2 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163738-B2 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-20080306050-A1 | Aminodiazepines as Toll-Like Receptor Modulators | ARRAY BIOPHARMA INC. (CO) | 2008-12-11 | — | — | US | disclosed |
| US-20080306050-A1 | Aminodiazepines as Toll-Like Receptor Modulators | ARRAY BIOPHARMA INC. (CO) | 2008-12-11 | — | — | US | disclosed |
| WO-2007040840-A2 | AMINODIAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | ARRAY BIOPHARMA INC. (US) | 2007-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208801-A1 | Aminodiazepines as Toll-Like Receptor Modulators | TLR8, TLR1, TLR5 | NOS2 1457/4885NOS3 1265/4885NOS1 1598/4885 |
| US-20080306050-A1 | Aminodiazepines as Toll-Like Receptor Modulators | TLR8, TLR1, TLR5 | NOS2 1457/4885NOS3 1265/4885NOS1 1598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.