Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 4/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15215726 | 0.95 | SMN1; SMN2 (0.44) | RAB9AMEN1KMT2ASMN1; SMN2DHODH | |
| SCHEMBL15038511 | 0.83 | RAB9A (0.51) | RAB9AMEN1KMT2ASMN1; SMN2DHODH | |
| SCHEMBL15215720 | 0.79 | RAB9A (0.49) | RAB9AMEN1KMT2ASMN1; SMN2DHODH | |
| SCHEMBL15038504 | 0.75 | RAB9A (0.31) | RAB9AMEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL9469335 | 0.74 | RAB9A (0.60) | RAB9AMEN1KMT2ASMN1; SMN2DHODH | |
| SCHEMBL9838484 | 0.72 | RAB9A (0.54) | RAB9AMEN1KMT2ASMN1; SMN2DHODH | |
| SCHEMBL13131547 | 0.70 | NPSR1 (0.57) | MEN1KMT2ASMN1; SMN2NPSR1L3MBTL1 | |
| SCHEMBL9402422 | 0.69 | RAB9A (0.57) | RAB9AMEN1KMT2ASMN1; SMN2DHODH | |
| SCHEMBL10047675 | 0.68 | RAB9A (0.41) | RAB9AMEN1KMT2ASMN1; SMN2DHODH | |
| SCHEMBL11625992 | 0.67 | BCL2 (0.58) | MEN1KMT2ASMN1; SMN2NPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2604260-B1 | NOVEL HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | SHIONOGI & CO (JP) | 2017-05-10 | — | — | EP | disclosed |
| WO-2012020742-A1 | NOVEL HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | 塩野義製薬株式会社 (JP) | 2012-02-16 | — | — | WO | disclosed |