Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | LTA4H | P09960 | 1/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KLK7 | P49862 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | FABP7 | O15540 | 1/20 | 0.47 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14259334 | 0.86 | TDP1 (0.51) | ALDH1A1L3MBTL1LTA4HMTNR1AMTNR1B | |
| SCHEMBL11684699 | 0.86 | ALDH1A1 (0.74) | ALDH1A1L3MBTL1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL1171464 | 0.86 | ALDH1A1 (0.74) | ALDH1A1L3MBTL1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL3727812 | 0.83 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1MAPK1SMN1; SMN2KLK7 | |
| SCHEMBL6393931 | 0.83 | MMP2 (0.61) | ALDH1A1L3MBTL1LTA4HMTNR1AMTNR1B | |
| SCHEMBL7865853 | 0.82 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1MAPK1SMN1; SMN2KLK7 | |
| SCHEMBL28250075 | 0.81 | ALDH1A1 (0.66) | ALDH1A1L3MBTL1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL10049358 | 0.80 | MMP2 (0.66) | ALDH1A1L3MBTL1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL10049367 | 0.78 | MMP2 (0.73) | ALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL8231569 | 0.78 | MMP2 (0.73) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093386-B2 | Thioaryl substituted inhibitors of zinc proteases and their use | BRACCO IMAGING S.P.A (IT) | 2012-01-10 | — | — | US | disclosed |
| US-20090239829-A1 | THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE | BRACCO IMAGING SPA (IT) | 2009-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239829-A1 | THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE | SERPINB1, ZFX, MMP2 | ALDH1A1 1406/4885L3MBTL1 1167/4885MAPK1 4729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.