Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3921382 | 0.89 | EDNRA (0.50) | KDM4EHSD17B10KMT2APOLBALDH1A1 | |
| SCHEMBL10017894 | 0.86 | ALDH1A1 (0.46) | L3MBTL1NPC1TDP1KDM4EHSD17B10 | |
| SCHEMBL12780374 | 0.80 | PLA2G2A (0.53) | L3MBTL1NPC1PLA2G2AKDM4EHSD17B10 | |
| SCHEMBL31510193 | 0.80 | PLA2G2A (0.53) | L3MBTL1NPC1PLA2G2AKDM4EHSD17B10 | |
| SCHEMBL5009832 | 0.79 | EGLN2 (0.47) | KDM4EMAPTPOLBALDH1A1HPGD | |
| SCHEMBL10049565 | 0.78 | ALOX5 (0.47) | L3MBTL1NPC1KDM4ECYP1A2POLB | |
| SCHEMBL14235597 | 0.77 | PLA2G2A (0.50) | NPC1PLA2G2AKDM4EHSD17B10MEN1 | |
| SCHEMBL28655389 | 0.77 | PLA2G2A (0.55) | L3MBTL1PLA2G2AKDM4EHSD17B10MAPT | |
| SCHEMBL28655385 | 0.76 | PLA2G2A (0.49) | PLA2G2AKDM4EHSD17B10MAPTMEN1 | |
| SCHEMBL5007542 | 0.76 | CASP3 (0.50) | NPC1TDP1KDM4EHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120029018-A1 | 9-SUBSTITUTED PHENANTHRENE BASED TYLOPHORINE DERIVATIVES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120029018-A1 | 9-SUBSTITUTED PHENANTHRENE BASED TYLOPHORINE DERIVATIVES | ABCB1, TYMP, PAH | L3MBTL1 2727/4885NPC1 297/4885TDP1 387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.