Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12680058 | 0.81 | MCHR1 (0.52) | MCHR1 | |
| SCHEMBL29769123 | 0.80 | KMO (0.45) | KMOSLC22A12CYP11B1CYP11B2HDAC8 | |
| SCHEMBL7071662 | 0.80 | KMO (0.45) | KMOSLC22A12CYP11B1CYP11B2HDAC8 | |
| SCHEMBL13825590 | 0.78 | KMO (0.44) | KMOSLC22A12CYP11B1CYP11B2HDAC8 | |
| SCHEMBL12680052 | 0.77 | KMO (0.50) | KMOSLC22A12CYP11B1CYP11B2HDAC8 | |
| SCHEMBL13215774 | 0.76 | KMO (0.50) | KMOSLC22A12CYP11B1CYP11B2HDAC8 | |
| SCHEMBL14564403 | 0.76 | KMO (0.57) | KMOSLC22A12HDAC8POLB | |
| SCHEMBL29796402 | 0.76 | RECQL (0.56) | KMOPOLB | |
| SCHEMBL4023710 | 0.76 | GLS (0.67) | POLBGLSMAPT | |
| SCHEMBL13607689 | 0.75 | KMO (0.52) | KMOSLC22A12CYP11B1CYP11B2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273770-B2 | 5-pyridinone substituted indazoles | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-09-25 | — | — | US | disclosed |
| US-8101632-B2 | 5-furopyridinone substituted indazoles | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-20090318439-A1 | 5-FUROPYRIDINONE SUBSTITUTED INDAZOLES | ALBANY MOLECULAR RESEARCH, INC. (US) | 2009-12-24 | — | — | US | disclosed |
| US-20090082359-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | AMR TECHNOLOGY, INC. (US) | 2009-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082359-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | CYP3A5, PNPO, NDUFS3 | KMO 1270/4885SLC22A12 1437/4885CYP11B1 30/4885 |
| US-20090318439-A1 | 5-FUROPYRIDINONE SUBSTITUTED INDAZOLES | MCHR1, PRMT5, PRMT1 | KMO 2099/4885SLC22A12 4218/4885CYP11B1 368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.