Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLCG1 | P19174 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 5/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11017416 | 0.81 | ALDH1A1 (0.50) | CA2CA12CA9CA1MMP1 | |
| SCHEMBL3195077 | 0.79 | PLCG1 (0.59) | PLCG1CA2IDO1CA12CA9 | |
| SCHEMBL11964589 | 0.79 | ALDH1A1 (0.55) | CA2CA12CA9CA1KMT2A | |
| SCHEMBL2522787 | 0.79 | GAA (0.55) | CA2CA12CA9CA1MMP1 | |
| SCHEMBL1482097 | 0.78 | PSIP1 (0.54) | CA2CA12CA9CA1TDP1 | |
| Hydrochloric Acid SCHEMBL9463319 | 0.78 | GAA (0.59) | CA2CA12CA9CA1MMP1 | |
| SCHEMBL19645496 | 0.77 | PLCG1 (0.52) | PLCG1CA2KMT2ACYP3A4CYP2C9 | |
| SCHEMBL3253487 | 0.75 | PLCG1 (1.00) | PLCG1CA2IDO1CA12CA9 | |
| SCHEMBL6422563 | 0.75 | PKM (0.53) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL9704914 | 0.73 | PLCG1 (0.70) | PLCG1CA2IDO1CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027698-A1 | MUTANT HPGG MOTIF AND HDASH MOTIF DELTA-5 DESATURASES AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-03-01 | — | — | WO | disclosed |
| US-7887805-B2 | comprising two different chimeric anti-hEGFR (Epidermal Growth Factor Receptor) antibodies which show a new mechanism of action based on rapid and efficient receptor internalization, induction of terminal differentiation and subsequent tumour eradication in an animal model | SYMPHOGEN A/S (DK) | 2011-02-15 | — | — | US | disclosed |