Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.53 |
| ▸ | MMP13 | P45452 | 7/20 | 0.53 |
| ▸ | MMP8 | P22894 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MMP9 | P14780 | 2/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4071220 | 0.81 | PKM (0.54) | PKMMMP13MMP8HTTNPSR1 | |
| SCHEMBL6424729 | 0.79 | MMP13 (0.50) | PKMMMP13MMP8HTTNPSR1 | |
| SCHEMBL11964589 | 0.79 | ALDH1A1 (0.55) | PKMMEN1KMT2AHSD11B1ALDH1A1 | |
| SCHEMBL6708168 | 0.78 | PKM (0.64) | PKMMMP13MMP8HTTNPSR1 | |
| SCHEMBL3250372 | 0.78 | PKM (0.64) | PKMMMP13MMP8HTTNPSR1 | |
| SCHEMBL11017416 | 0.76 | ALDH1A1 (0.50) | MMP13MMP8MMP1MEN1KMT2A | |
| SCHEMBL9705169 | 0.76 | PKM (0.61) | PKMMMP13MMP8HTTNPSR1 | |
| SCHEMBL3369176 | 0.75 | ALDH1A1 (0.65) | PKMMMP13MMP8MMP1MMP9 | |
| SCHEMBL14468640 | 0.75 | PKM (0.59) | PKMMMP13MMP8HTTNPSR1 | |
| SCHEMBL2522787 | 0.75 | GAA (0.55) | PKMMMP13MMP8HTTMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929519-B1 | BETA-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS | UPJOHN CO (US) | 2005-02-23 | — | — | EP | claimed |