Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | NQO2 | P16083 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15120000 | 0.91 | ALDH1A1 (0.52) | ACHEALDH1A1CYP1A2CYP3A4NQO2 | |
| Difucol Hexamethyl Ether SCHEMBL505203 | 0.82 | CYP1A2 (0.60) | ACHEALDH1A1CYP1A2CYP3A4NQO2 | |
| SCHEMBL26328948 | 0.82 | ALDH1A1 (0.44) | ACHEALDH1A1CYP1A2CYP3A4NQO2 | |
| SCHEMBL15119996 | 0.80 | ALDH1A1 (0.43) | ACHEALDH1A1CYP1A2CYP3A4NQO2 | |
| SCHEMBL12326164 | 0.77 | ALDH1A1 (0.59) | ACHEALDH1A1CYP1A2CYP3A4PTPN1 | |
| SCHEMBL17930308 | 0.75 | MAPT (0.49) | ALDH1A1CYP1A2CYP3A4CA12CA1 | |
| SCHEMBL16624733 | 0.75 | ACHE (0.42) | ACHEALDH1A1CYP1A2CYP3A4PTPN1 | |
| SCHEMBL26201033 | 0.73 | ACHE (0.45) | ACHEALDH1A1CRHR1 | |
| SCHEMBL15488875 | 0.73 | ACHE (0.41) | ACHEALDH1A1CYP1A2CYP3A4PTPN1 | |
| SCHEMBL890469 | 0.73 | ERN1 (0.46) | ACHEALDH1A1CYP1A2CYP3A4PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273021-B2 | Dibenzofuran derivatives as inhibitors of fructose 1,6-bisphosphatase and methods of use thereof | TRUSTEES OF BOSTON COLLEGE (US) | 2016-03-01 | — | — | US | disclosed |
| US-20120028892-A1 | INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE AND METHODS OF USE THEREOF | TRUSTEES OF BOSTON COLLEGE (US) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028892-A1 | INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE AND METHODS OF USE THEREOF | FBP1, SLC5A1, ALDOA | ACHE 1565/4885ALDH1A1 279/4885CYP1A2 429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.