SCHEMBL10052084

SCHEMBL10052084

COC(=O)Cc1ccc(-c2cc(-c3ccccn3)nc(-c3ccccn3)c2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.50
ALDH1A1 P00352 1/20 0.50
APOBEC3G Q9HC16 1/20 0.50
PKM P14618 2/20 0.49
RAB9A P51151 2/20 0.49
LMNA P02545 2/20 0.49
WNT3A P56704 2/20 0.48
SMN1; SMN2 Q16637 2/20 0.47
NPC1 O15118 1/20 0.47
HPGD P15428 1/20 0.47
NFKB1 P19838 1/20 0.47
NFKB2 Q00653 1/20 0.47
RELA Q04206 1/20 0.47
MEN1 O00255 1/20 0.44
SLC6A2 P23975 1/20 0.44
SLC6A3 Q01959 1/20 0.44
KMT2A Q03164 1/20 0.44
SQOR Q9Y6N5 1/20 0.44
ADORA3 P0DMS8 1/20 0.43
RIOK2 Q9BVS4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12869882 0.86 LMNA (0.55) KDM4EALDH1A1APOBEC3GPKMRAB9A
SCHEMBL23011276 0.83 LMNA (0.42) KDM4EALDH1A1APOBEC3GLMNAWNT3A
SCHEMBL10020883 0.80 KDM4E (0.57) KDM4EALDH1A1PKMRAB9ASMN1; SMN2
SCHEMBL26078072 0.80 LMNA (0.42) KDM4EALDH1A1APOBEC3GLMNAWNT3A
SCHEMBL9228056 0.78 CCR1 (0.50) KDM4EALDH1A1PKMRAB9ALMNA
SCHEMBL4768334 0.77 KDM4E (0.53) KDM4EALDH1A1APOBEC3GPKMRAB9A
SCHEMBL13311187 0.77 CCR1 (0.64) KDM4EALDH1A1PKMRAB9ALMNA
SCHEMBL29660049 0.77 CCR1 (0.64) KDM4EALDH1A1PKMRAB9ALMNA
SCHEMBL2007559 0.77 CCR1 (0.64) KDM4EALDH1A1PKMRAB9ALMNA
SCHEMBL1428025 0.75 LMNA (0.62) KDM4EALDH1A1PKMRAB9ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120052423-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2012-03-01 US disclosed