Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.48 |
| ▸ | RAD52 | P43351 | 5/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1004329 | 0.87 | HTR3A (0.41) | TOP2ARAD52SMARCA2HTR3AKDM4E | |
| SCHEMBL1004894 | 0.85 | TOP2A (0.50) | TOP2AHTR3ARIPK1KDM4EALDH1A1 | |
| SCHEMBL1005709 | 0.84 | TOP2A (0.49) | TOP2AHTR3ARIPK1KDM4EALDH1A1 | |
| SCHEMBL1005317 | 0.84 | HTR3A (0.54) | TOP2AHTR3ARIPK1KDM4EALDH1A1 | |
| SCHEMBL1006044 | 0.83 | TOP2A (0.48) | TOP2AHTR3ARIPK1KDM4EALDH1A1 | |
| SCHEMBL1006003 | 0.83 | TOP2A (0.48) | TOP2AHTR3ARIPK1KDM4EALDH1A1 | |
| SCHEMBL1004169 | 0.80 | TOP2A (0.49) | TOP2ARAD52SMARCA2HTR3ARIPK1 | |
| SCHEMBL1006138 | 0.80 | TOP2A (0.49) | TOP2AHTR3ARIPK1KDM4EALDH1A1 | |
| SCHEMBL1005701 | 0.79 | TOP2A (0.56) | TOP2AHTR3ARIPK1KDM4EALDH1A1 | |
| SCHEMBL1005576 | 0.78 | ALDH1A1 (0.46) | TOP2AHTR3AKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101528225-B | 2-aminobenzoxazole carboxamides as 5HT3 modulators | ALBANY MOLECULAR RES INC | 2013-07-17 | — | — | CN | disclosed |
| US-7863271-B2 | 2-aminobenzoxazole carboxamides as 5HT3 modulators | ALBANY MOLECULAR RESEARCH, INC. (US) | 2011-01-04 | — | — | US | disclosed |
| CN-101528225-A | 2-aminobenzoxazole carboxamides as 5HT3 modulators | AMR TECHNOLOGY INC (US) | 2009-09-09 | — | — | CN | disclosed |
| EP-2061460-A2 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | Albany Molecular Research, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| US-20080255114-A1 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | AMR TECHNOLOGY, INC. (US) | 2008-10-16 | — | — | US | disclosed |
| WO-2008019372-A2 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | ALBANY MOLECULAR RESEARCH, INC. (US) | 2008-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255114-A1 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | HTR3E, HTR3C, HTR3A | TOP2A 323/4885RAD52 2663/4885SMARCA2 1854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.