Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 8/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.80 |
| ▸ | MEN1 | O00255 | 7/20 | 0.80 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.78 |
| ▸ | GAA | P10253 | 2/20 | 0.78 |
| ▸ | HSPA1A | P0DMV8 | 10/20 | 0.72 |
| ▸ | PTPN7 | P35236 | 10/20 | 0.72 |
| ▸ | GAPDH | P04406 | 6/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | BLM | P54132 | 3/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.72 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.72 |
| ▸ | RECQL | P46063 | 2/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.72 |
| ▸ | APEX1 | P27695 | 1/20 | 0.72 |
| ▸ | MASP2 | O00187 | 3/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6215376 | 0.89 | POLB (0.77) | POLBKMT2AMEN1L3MBTL1GAA | |
| SCHEMBL26458981 | 0.88 | KMT2A (1.00) | POLBKMT2AMEN1L3MBTL1GAA | |
| SCHEMBL23949487 | 0.88 | KMT2A (1.00) | POLBKMT2AMEN1L3MBTL1GAA | |
| SCHEMBL10022369 | 0.88 | POLB (0.75) | POLBKMT2AMEN1L3MBTL1GAA | |
| SCHEMBL2116528 | 0.84 | PTPN7 (1.00) | POLBKMT2AMEN1L3MBTL1GAA | |
| SCHEMBL1066515 | 0.79 | PTPN7 (1.00) | POLBKMT2AMEN1L3MBTL1GAA | |
| SCHEMBL13856706 | 0.79 | PTPN7 (1.00) | POLBKMT2AMEN1L3MBTL1GAA | |
| SCHEMBL15321796 | 0.76 | AR (0.58) | POLBKMT2AMEN1L3MBTL1GAA | |
| SCHEMBL15321060 | 0.75 | AR (0.57) | POLBKMT2AMEN1L3MBTL1GAA | |
| SCHEMBL6085506 | 0.75 | GAPDH (0.69) | POLBKMT2AMEN1L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590950-B1 | N-CYCLYL-3-(CYCLYLCARBONYLAMINOMETHYL)BENZAMIDE DERIVATIVES AS RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2014-10-15 | — | — | EP | disclosed |
| US-20120165322-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | US | disclosed |
| WO-2012006203-A1 | N-CYCLYL-3 - (CYCLYLCARBONYLAMINOMETHYL) BENZAMIDE DERIVATIVES AS RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165322-A1 | RHO KINASE INHIBITORS | ROCK1, ROCK2, RHOA | POLB 2716/4885KMT2A 3143/4885MEN1 1338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.