Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAPDH | P04406 | 4/20 | 0.69 |
| ▸ | HSPA1A | P0DMV8 | 4/20 | 0.69 |
| ▸ | HSPA8 | P11142 | 2/20 | 0.69 |
| ▸ | AR | P10275 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 7/20 | 0.58 |
| ▸ | POLB | P06746 | 7/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | PTPN7 | P35236 | 6/20 | 0.47 |
| ▸ | BLM | P54132 | 3/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6214303 | 0.83 | GAPDH (0.57) | GAPDHHSPA1AHSPA8ARMEN1 | |
| SCHEMBL6087749 | 0.82 | HSPA1A (1.00) | GAPDHHSPA1AHSPA8MEN1POLB | |
| SCHEMBL6701529 | 0.81 | HSPA1A (0.79) | GAPDHHSPA1AHSPA8MEN1POLB | |
| SCHEMBL6215376 | 0.80 | POLB (0.77) | GAPDHHSPA1AHSPA8ARMEN1 | |
| SCHEMBL6675758 | 0.79 | GAPDH (0.56) | GAPDHHSPA1AHSPA8ARMEN1 | |
| SCHEMBL6211359 | 0.79 | GAPDH (0.41) | GAPDHHSPA1AHSPA8MEN1POLB | |
| SCHEMBL10053590 | 0.75 | POLB (0.80) | GAPDHHSPA1AHSPA8ARMEN1 | |
| SCHEMBL6214848 | 0.74 | GAPDH (0.68) | GAPDHHSPA1AHSPA8MEN1POLB | |
| SCHEMBL23949487 | 0.72 | KMT2A (1.00) | GAPDHHSPA1AHSPA8ARMEN1 | |
| SCHEMBL10022369 | 0.72 | POLB (0.75) | GAPDHHSPA1AHSPA8ARMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254118-B1 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | GRUENENTHAL GMBH (DE) | 2005-11-09 | — | — | EP | claimed |
| US-6699877-B2 | TREATING PAIN, MIGRAINE, AND VARIOUS OTHER DISEASES | GRUENENTHAL GMBH (DE) | 2004-03-02 | — | — | US | claimed |
| US-20030087926-A1 | Substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid derivatives | GRUENENTHAL GMBH | 2003-05-08 | — | — | US | claimed |
| US-7145011-B2 | Method for the production of substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acids | GRUNENTHAL GMBH (DE) | 2006-12-05 | — | — | US | disclosed |
| US-20050004366-A1 | Method for the production of substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acids | PRZEWOSNY MICHAEL THOMAS (DE) | 2005-01-06 | — | — | US | disclosed |
| US-6699877-B2 | TREATING PAIN, MIGRAINE, AND VARIOUS OTHER DISEASES | GRUENENTHAL GMBH (DE) | 2004-03-02 | — | — | US | disclosed |
| US-20030087926-A1 | Substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid derivatives | GRUENENTHAL GMBH | 2003-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087926-A1 | Substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid derivatives | SDHA, CACNA1A, GRIN2C | GAPDH 1284/4885HSPA1A 3371/4885HSPA8 4627/4885 |
| US-20050004366-A1 | Method for the production of substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acids | CBR3, DDC, PCCA | GAPDH 799/4885HSPA1A 3090/4885HSPA8 3607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.