SCHEMBL10053647

SCHEMBL10053647

CC1=Cc2c(cccc2N(C)c2ccccc2)C1[Si](C)(C)C1C(C)=Cc2c1cccc2N(C)c1ccccc1

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
PIM1 P11309 1/20 0.31
EGFR P00533 1/20 0.31
CHKA P35790 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3763925 1.00 MEN1 (0.32) MEN1KMT2APIM1EGFRCHKA
SCHEMBL3664833 0.87
SCHEMBL3661620 0.77
Hydrochloric Acid SCHEMBL3770222 0.74
Hydrochloric Acid SCHEMBL3768347 0.73
SCHEMBL1454519 0.73 HTR2C (0.31)
SCHEMBL29366427 0.73 PDCD1 (0.34)
SCHEMBL61908 0.73 PDCD1 (0.34)
SCHEMBL3768349 0.72
SCHEMBL8369933 0.72 IDO1 (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8207281-B2 Process for preparing transition metal compounds for olefins polymerization BASELL POLYOLEFINE GMBH (DE) 2012-06-26 US disclosed
US-20100311926-A1 PROCESS FOR PREPARING TRANSITION METAL COMPOUNDS FOR OLEFINS POLYMERIZATION BASELL POLYOLEFINE GMBH (DE) 2010-12-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100311926-A1 PROCESS FOR PREPARING TRANSITION METAL COMPOUNDS FOR OLEFINS POLYMERIZATION FES, AP1S1, NBAS MEN1 1774/4885KMT2A 1451/4885PIM1 563/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.