Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.80 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | ACE | P12821 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20248172 | 1.00 | HPGD (0.80) | HPGDL3MBTL1ACENPC1RAB9A | |
| SCHEMBL10053703 | 0.89 | HPGD (1.00) | HPGDL3MBTL1ACENPC1RAB9A | |
| SCHEMBL10054188 | 0.88 | HPGD (0.80) | HPGDL3MBTL1ACENPC1RAB9A | |
| SCHEMBL28052500 | 0.78 | L3MBTL1 (0.66) | HPGDL3MBTL1NPC1RAB9ATDP1 | |
| SCHEMBL29560919 | 0.78 | L3MBTL1 (0.66) | HPGDL3MBTL1NPC1RAB9ATDP1 | |
| SCHEMBL14946437 | 0.76 | HPGD (0.63) | HPGDACENPC1RAB9ATDP1 | |
| SCHEMBL28655184 | 0.76 | TDP1 (0.63) | HPGDACETDP1TSHRLMNA | |
| SCHEMBL12783352 | 0.76 | ACE (0.70) | HPGDACENPC1RAB9ATDP1 | |
| SCHEMBL17278349 | 0.75 | ACE (0.68) | HPGDACENPC1RAB9ATDP1 | |
| SCHEMBL10422997 | 0.74 | ACE (0.67) | HPGDACENPC1RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8906945-B2 | Inhibitors of bacterial type III secretion system | MICROBIOTIX, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20120114633-A1 | Inhibitors Of Bacterial Type III Secretion System | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114633-A1 | Inhibitors Of Bacterial Type III Secretion System | CLPP, TFPI, SI | HPGD 2656/4885L3MBTL1 3356/4885ACE 2802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.