Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 2/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5268403 | 1.00 | KHK (0.52) | KHKADRA2AADRA2BADRA2CTLR9 | |
| SCHEMBL15378488 | 0.90 | KHK (0.57) | KHKADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL4246315 | 0.90 | KHK (0.57) | KHKADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL4246310 | 0.90 | KHK (0.57) | KHKADRA2AADRA2BADRA2CMAPT | |
| Hydrochloric Acid SCHEMBL15819287 | 0.88 | KHK (0.56) | KHKADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL15579346 | 0.86 | HTR7 (0.62) | KHKMAPTUSP2ALDH1A1TP53 | |
| SCHEMBL2246734 | 0.85 | CSNK1E (0.46) | KHKADRA2AADRA2BADRA2CTLR9 | |
| SCHEMBL5272469 | 0.85 | CSNK1E (0.46) | KHKADRA2AADRA2BADRA2CTLR9 | |
| SCHEMBL2246868 | 0.85 | TLR9 (0.44) | KHKADRA2AADRA2BADRA2CTLR9 | |
| SCHEMBL5274527 | 0.83 | ADRB1 (0.57) | TLR9TLR8TLR7MAPTADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263628-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2011-10-27 | — | — | US | claimed |
| US-20080021028-A1 | N-Hydroxyamide Derivatives and Use Thereof | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2008-01-24 | — | — | US | claimed |
| US-8247437-B2 | N-hydroxyamide derivatives and use thereof | MERCK SERONO SA (CH) | 2012-08-21 | — | — | US | disclosed |
| US-8198280-B2 | N-hydroxyamide derivatives and use thereof | MERCK SERONO SA (CH) | 2012-06-12 | — | — | US | disclosed |
| US-8198280-B2 | N-hydroxyamide derivatives and use thereof | MERCK SERONO SA (CH) | 2012-06-12 | — | — | US | disclosed |
| US-8198280-B2 | N-hydroxyamide derivatives and use thereof | MERCK SERONO SA (CH) | 2012-06-12 | — | — | US | disclosed |
| US-20110263628-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2011-10-27 | — | — | US | disclosed |
| US-8008302-B2 | ((2S,3S) N,2-dihydroxy-5-methyl-3-{[4-(2-pyridinyl)-1-piperazinyl]carbonyl}hexanamide; for treatment and/or prevention of disorders related to autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, stroke, cancer, pre-term labor, endometriosis | MERCK SERONO SA (CH) | 2011-08-30 | — | — | US | disclosed |
| EP-1844032-B1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | MERCK SERONO SA (CH) | 2011-07-13 | — | — | EP | disclosed |
| US-20110086864-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | MERCK SERONO SA (CH) | 2011-04-14 | — | — | US | disclosed |
| US-20110086864-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | MERCK SERONO SA (CH) | 2011-04-14 | — | — | US | disclosed |
| US-7868009-B2 | N-hydroxyamide derivatives and use thereof | Merck Serono, S.A. (CH) | 2011-01-11 | — | — | US | disclosed |
| US-7868009-B2 | N-hydroxyamide derivatives and use thereof | Merck Serono, S.A. (CH) | 2011-01-11 | — | — | US | disclosed |
| US-7868009-B2 | N-hydroxyamide derivatives and use thereof | Merck Serono, S.A. (CH) | 2011-01-11 | — | — | US | disclosed |
| EP-1771421-B1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | SERONO LAB (CH) | 2009-04-29 | — | — | EP | disclosed |
| US-20080090838-A1 | N-Hydroxyamide Derivatives and Use Thereof | LABORATOIRES SERONO S.A. (CH) | 2008-04-17 | — | — | US | disclosed |
| US-20080090838-A1 | N-Hydroxyamide Derivatives and Use Thereof | LABORATOIRES SERONO S.A. (CH) | 2008-04-17 | — | — | US | disclosed |
| US-20080090838-A1 | N-Hydroxyamide Derivatives and Use Thereof | LABORATOIRES SERONO S.A. (CH) | 2008-04-17 | — | — | US | disclosed |
| US-20080021028-A1 | N-Hydroxyamide Derivatives and Use Thereof | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2008-01-24 | — | — | US | disclosed |
| WO-2006079653-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2006-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086864-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | HNMT, HCAR2, HPGD | KHK 2364/4885ADRA2A 576/4885ADRA2B 650/4885 |
| US-20080090838-A1 | N-Hydroxyamide Derivatives and Use Thereof | HNMT, ALOX5, HCAR2 | KHK 2354/4885ADRA2A 618/4885ADRA2B 718/4885 |
| US-20110263628-A1 | N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF | HNMT, HCAR2, HPGD | KHK 2364/4885ADRA2A 576/4885ADRA2B 650/4885 |
| US-20080021028-A1 | N-Hydroxyamide Derivatives and Use Thereof | HCAR2, HNMT, HPGD | KHK 2324/4885ADRA2A 539/4885ADRA2B 646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.