SCHEMBL10058413

SCHEMBL10058413

CC(C)OC(=O)N1CCC(O[C@H](C)c2nc(-c3cnc(N4C[C@H](c5ccc(F)cc5F)[C@@H](N)C4)nc3)no2)CC1

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 12/20 0.47
DPP4 P27487 2/20 0.37
DPP7 Q9UHL4 1/20 0.37
MC4R P32245 1/20 0.36
ALDH1A1 P00352 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
RAB9A P51151 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10058415 0.94 GPR119 (0.47) GPR119DPP4DPP7ALDH1A1NPSR1
SCHEMBL610227 0.93 GPR119 (0.45) GPR119DPP4ALDH1A1RAB9A
SCHEMBL10058417 0.92 GPR119 (0.46) GPR119DPP4DPP7
SCHEMBL10058419 0.88 GPR119 (0.39) GPR119DPP4DPP7
SCHEMBL609291 0.88 GPR119 (0.45) GPR119ALDH1A1RAB9A
SCHEMBL10058411 0.87 GPR119 (0.44) GPR119MC4RALDH1A1NPSR1
SCHEMBL10058408 0.86 GPR119 (0.48) GPR119DPP4DPP7ALDH1A1NPSR1
SCHEMBL609212 0.86 GPR119 (0.44) GPR119DPP4ALDH1A1NPSR1RAB9A
SCHEMBL10058406 0.84 GPR119 (0.47) GPR119ALDH1A1NPSR1
SCHEMBL611803 0.83 GPR119 (0.43) GPR119DPP4DPP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120040953-A1 Compounds for the Treatment of Metabolic Disorders PROSIDION LIMITED (GB) 2012-02-16 US disclosed
US-20120040953-A1 Compounds for the Treatment of Metabolic Disorders PROSIDION LIMITED (GB) 2012-02-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120040953-A1 Compounds for the Treatment of Metabolic Disorders GPR119, GPR132, FFAR2 GPR119 1/4885DPP4 217/4885DPP7 276/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.