SCHEMBL10058415

SCHEMBL10058415

CC(C)OC(=O)N1CCC(O[C@H](C)c2nc(-c3cnc(N4C[C@H](c5cc(F)ccc5F)[C@@H](N)C4)nc3)no2)CC1

nearest known ligand 0.47

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 16/20 0.47
MCHR1 Q99705 2/20 0.36
DPP4 P27487 1/20 0.36
DPP7 Q9UHL4 1/20 0.36
ALDH1A1 P00352 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10058413 0.94 GPR119 (0.47) GPR119DPP4DPP7ALDH1A1NPSR1
SCHEMBL10058419 0.94 GPR119 (0.39) GPR119MCHR1DPP4DPP7
SCHEMBL609291 0.93 GPR119 (0.45) GPR119ALDH1A1
SCHEMBL10058417 0.92 GPR119 (0.46) GPR119DPP4DPP7
SCHEMBL10058408 0.92 GPR119 (0.48) GPR119MCHR1DPP4DPP7ALDH1A1
SCHEMBL611803 0.89 GPR119 (0.43) GPR119MCHR1DPP4DPP7
SCHEMBL13186630 0.88 GPR119 (0.37) GPR119MCHR1DPP4
SCHEMBL609301 0.88 GPR119 (0.37) GPR119MCHR1DPP4
SCHEMBL610227 0.88 GPR119 (0.45) GPR119DPP4ALDH1A1
SCHEMBL612024 0.88 GPR119 (0.39) GPR119MCHR1DPP4DPP7ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120040953-A1 Compounds for the Treatment of Metabolic Disorders PROSIDION LIMITED (GB) 2012-02-16 US disclosed
US-20120040953-A1 Compounds for the Treatment of Metabolic Disorders PROSIDION LIMITED (GB) 2012-02-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120040953-A1 Compounds for the Treatment of Metabolic Disorders GPR119, GPR132, FFAR2 GPR119 1/4885MCHR1 498/4885DPP4 217/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.