Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 10/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.51 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10060139 | 0.90 | HDAC4 (0.50) | HDAC4HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL10060141 | 0.85 | KDM1A (0.57) | GRIN1GRIN2APDE4APDE4BPDE4C | |
| SCHEMBL1979577 | 0.84 | PADI4 (0.63) | GRIN1GRIN2APDE4APDE4BPDE4C | |
| SCHEMBL20138329 | 0.84 | PADI4 (0.63) | GRIN1GRIN2APDE4APDE4BPDE4C | |
| SCHEMBL10061251 | 0.83 | PDE4A (0.57) | HDAC4HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL1009191 | 0.81 | HDAC4 (0.47) | HDAC4HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL10060235 | 0.80 | KDM1A (0.59) | PADI6PADI4PADI2 | |
| SCHEMBL10060238 | 0.79 | PADI6 (0.55) | HDAC4HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL18941863 | 0.78 | HDAC4 (0.45) | HDAC4HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL10060566 | 0.78 | PADI6 (0.69) | PDE4APDE4BPDE4CPDE4DPADI6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8969333-B2 | Therapeutic compositions and methods | THE PENN STATE RESEARCH FOUNDATION (US) | 2015-03-03 | — | — | US | disclosed |
| US-20140288059-A1 | THERAPEUTIC COMPOSITIONS AND METHODS | THE PENN STATE RESEARCH FOUNDATION (US) | 2014-09-25 | — | — | US | disclosed |
| US-20120108562-A1 | THERAPEUTIC COMPOSITIONS AND METHODS | THE PENN STATE RESEARCH FOUNDATION (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140288059-A1 | THERAPEUTIC COMPOSITIONS AND METHODS | PADI4, PADI2, PADI3 | HDAC4 42/4885HDAC3 458/4885HDAC1 602/4885 |
| US-20120108562-A1 | THERAPEUTIC COMPOSITIONS AND METHODS | PADI4, PADI2, PADI3 | HDAC4 42/4885HDAC3 458/4885HDAC1 602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.