Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 5/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 2/20 | 0.49 |
| ▸ | GALR3 | O60755 | 2/20 | 0.47 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.47 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL713528 | 0.91 | KIT (0.56) | KITPDGFRAFLT3GALR3NR2F2 | |
| SCHEMBL711881 | 0.88 | KIT (0.54) | KITPDGFRAFLT3PARP1SLC6A7 | |
| SCHEMBL10029631 | 0.86 | PARP1 (0.51) | LOXL2PARP1MAPK10MAPK8SLC6A7 | |
| SCHEMBL713524 | 0.83 | KIT (0.57) | KITPDGFRAFLT3EGFRRAB9A | |
| SCHEMBL713649 | 0.81 | SLC6A7 (0.52) | GALR3NR2F2EGFRRAB9AMAPK10 | |
| SCHEMBL713670 | 0.79 | SLC6A7 (0.54) | MAPK10MAPK8SLC6A7LMNATSHR | |
| SCHEMBL714936 | 0.78 | MAPT (0.57) | EGFRRAB9ASLC6A7LMNAMAPK1 | |
| SCHEMBL713933 | 0.78 | MEN1 (0.55) | SLC6A7LMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL3640288 | 0.74 | PDE5A (0.68) | RAB9AMAPK10SLC6A7LMNAMAPK1 | |
| SCHEMBL715211 | 0.73 | RAB9A (0.55) | KITPDGFRAFLT3EGFRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027495-A1 | PIPERAZINYLPYRIMIDINE ANALOGUES AS PROTEIN KINASE INHIBITORS | UNIVERSITY OF THE PACIFIC (US) | 2012-03-01 | — | — | WO | disclosed |