Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL714936 | 0.90 | MAPT (0.57) | RAB9AMEN1KMT2ASLC6A7POLB | |
| SCHEMBL713524 | 0.90 | KIT (0.57) | RAB9AMEN1KMT2ASLC6A7TNKS | |
| SCHEMBL713649 | 0.88 | SLC6A7 (0.52) | RAB9AMEN1KMT2ASLC6A7HDAC1 | |
| SCHEMBL711881 | 0.80 | KIT (0.54) | SLC6A7POLBMAPTSMN1; SMN2LMNA | |
| SCHEMBL713528 | 0.78 | KIT (0.56) | RAB9ASLC6A7HDAC1SMN1; SMN2LMNA | |
| SCHEMBL715005 | 0.78 | ABCG2 (0.53) | MEN1KMT2ASLC6A7TNKSPIK3CG | |
| SCHEMBL715544 | 0.77 | SLC6A7 (0.52) | MEN1KMT2ASLC6A7MAPTLMNA | |
| SCHEMBL3588194 | 0.77 | SLC6A7 (0.74) | MEN1KMT2ASLC6A7POLBLMNA | |
| SCHEMBL15014071 | 0.73 | EGFR (0.69) | RAB9AMEN1KMT2APOLBMAPT | |
| SCHEMBL10061589 | 0.73 | KIT (0.54) | RAB9ASLC6A7SMN1; SMN2LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609672-B2 | Piperazinylpyrimidine analogues as protein kinase inhibitors | UNIVERSITY OF THE PACIFIC (US) | 2013-12-17 | — | — | US | disclosed |
| US-20120053183-A1 | PIPERAZINYLPYRIMIDINE ANALOGUES AS PROTEIN KINASE INHIBITORS | UNIVERSITY OF THE PACIFIC (US) | 2012-03-01 | — | — | US | disclosed |
| WO-2012027495-A1 | PIPERAZINYLPYRIMIDINE ANALOGUES AS PROTEIN KINASE INHIBITORS | UNIVERSITY OF THE PACIFIC (US) | 2012-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053183-A1 | PIPERAZINYLPYRIMIDINE ANALOGUES AS PROTEIN KINASE INHIBITORS | DCK, PAK5, CDK2 | RAB9A 2724/4885MEN1 3873/4885KMT2A 1149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.