Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.56 |
| ▸ | GALR3 | O60755 | 2/20 | 0.52 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10061589 | 0.91 | KIT (0.54) | KITPDGFRAFLT3SLC6A7GALR3 | |
| SCHEMBL713649 | 0.90 | SLC6A7 (0.52) | SLC6A7GALR3NR2F2EGFRRAB9A | |
| SCHEMBL713524 | 0.88 | KIT (0.57) | KITPDGFRAFLT3SLC6A7EGFR | |
| SCHEMBL713670 | 0.88 | SLC6A7 (0.54) | SLC6A7LMNATSHRMAPK1MAPK10 | |
| SCHEMBL711881 | 0.82 | KIT (0.54) | KITPDGFRAFLT3SLC6A7LMNA | |
| SCHEMBL715544 | 0.79 | SLC6A7 (0.52) | SLC6A7LMNATSHRMAPK10MAPK8 | |
| SCHEMBL715211 | 0.78 | RAB9A (0.55) | KITPDGFRAFLT3SLC6A7EGFR | |
| SCHEMBL715005 | 0.78 | ABCG2 (0.53) | KITPDGFRAFLT3SLC6A7TSHR | |
| SCHEMBL3640288 | 0.78 | PDE5A (0.68) | SLC6A7RAB9ALMNAMAPK1HTT | |
| SCHEMBL10029631 | 0.77 | PARP1 (0.51) | SLC6A7MAPK10MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609672-B2 | Piperazinylpyrimidine analogues as protein kinase inhibitors | UNIVERSITY OF THE PACIFIC (US) | 2013-12-17 | — | — | US | disclosed |
| US-20120053183-A1 | PIPERAZINYLPYRIMIDINE ANALOGUES AS PROTEIN KINASE INHIBITORS | UNIVERSITY OF THE PACIFIC (US) | 2012-03-01 | — | — | US | disclosed |
| WO-2012027495-A1 | PIPERAZINYLPYRIMIDINE ANALOGUES AS PROTEIN KINASE INHIBITORS | UNIVERSITY OF THE PACIFIC (US) | 2012-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053183-A1 | PIPERAZINYLPYRIMIDINE ANALOGUES AS PROTEIN KINASE INHIBITORS | DCK, PAK5, CDK2 | KIT 964/4885PDGFRA 587/4885FLT3 345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.