Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2223643 | 0.82 | HPGD (0.32) | CYP2D6ALDH1A1MCOLN3CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL4523224 | 0.81 | KDM4E (0.31) | CYP2D6CYP1A2CYP2C19NPSR1 | |
| Hydrochloric Acid SCHEMBL17836910 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL1007232 | 0.77 | HSD11B1 (0.35) | ALDH1A1HSD11B1GAA | |
| Hydrochloric Acid SCHEMBL17836900 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL17836926 | 0.75 | TSHR (0.38) | ALDH1A1MCOLN3KMT2AL3MBTL1MAPK1 | |
| Hydrochloric Acid SCHEMBL1007082 | 0.73 | TACR1 (0.31) | — | |
| Hydrochloric Acid SCHEMBL1006905 | 0.72 | KMT2A (0.32) | OPRM1KMT2A | |
| Hydrochloric Acid SCHEMBL1007345 | 0.72 | SLC18A3 (0.31) | — | |
| Hydrochloric Acid SCHEMBL4576653 | 0.69 | CYP2D6 (0.38) | CYP2D6ALDH1A1MCOLN3CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2270063-B1 | PROCESS FOR PRODUCING HYDROGENATED PRODUCT OF CYCLIC OLEFIN POLYMER PREPARED THROUGH RING-OPENING POLYMERIZATION | ZEON CORP (JP) | 2016-03-23 | — | — | EP | disclosed |
| EP-1197509-B1 | PROCESS FOR PRODUCING HYDROGENATED RING-OPENING POLYMERIZATION POLYMER OF CYCLOOLEFIN | ZEON CORP (JP) | 2011-07-06 | — | — | EP | disclosed |
| EP-2270063-A2 | Process for producing hydrogenated product of cyclic olefin polymer prepared through ring-opening polymerization | NIPPON ZEON CO., LTD. (JP) | 2011-01-05 | — | — | EP | disclosed |
| US-6908970-B2 | Process for producing hydrogenated product of cyclic olefin polymer prepared through ring-opening polymerization | ZEON CORPORATION (JP) | 2005-06-21 | — | — | US | disclosed |
| US-20030050406-A1 | Process for producing hydrogenated product of cyclic olefin polymer prepared through ring-opening polymerization | ZEON CORPORATION | 2003-03-13 | — | — | US | disclosed |
| US-6486264-B1 | Process for producing hydrogenated ring-opening polymerization polymer of cycloolefin | ZEON CORPORATION (JP) | 2002-11-26 | — | — | US | disclosed |
| EP-1197509-A1 | PROCESS FOR PRODUCING HYDROGENATED RING-OPENING POLYMERIZATION POLYMER OF CYCLOOLEFIN | Nippon Zeon Co., Ltd. (JP) | 2002-04-17 | — | — | EP | disclosed |