Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 4/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15202948 | 0.92 | HTR2C (0.42) | OPRM1OPRK1OPRL1IDO1HTR2C | |
| SCHEMBL10063160 | 0.89 | OPRM1 (0.42) | OPRM1OPRK1OPRL1HTR2CHTR2A | |
| SCHEMBL20230166 | 0.73 | IDO1 (0.37) | IDO1HTR2CHTR2BCCR3PARP2 | |
| SCHEMBL15202991 | 0.72 | OPRM1 (0.56) | OPRM1OPRK1OPRL1HTR2CHTR2A | |
| SCHEMBL181875 | 0.72 | OPRM1 (0.36) | OPRM1OPRK1OPRL1HTR2CHTR2B | |
| SCHEMBL26869656 | 0.72 | GRIA1 (0.36) | OPRM1OPRK1OPRL1HTR2CHTR2B | |
| SCHEMBL9775096 | 0.71 | PARK7 (0.41) | IDO1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL5546064 | 0.71 | CCR3 (0.38) | OPRM1OPRL1HTR2CHTR2AHTR2B | |
| SCHEMBL23034828 | 0.69 | OPRM1 (0.40) | OPRM1OPRK1OPRL1HTR2CHTR2A | |
| SCHEMBL10062766 | 0.69 | OPRM1 (0.43) | OPRM1OPRK1OPRL1HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020813-A1 | FUSED-RING PYRROLIDINE DERIVATIVE | 大日本住友製薬株式会社 (JP) | 2012-02-16 | — | — | WO | disclosed |