Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 15/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10209306 | 1.00 | P2RX7 (0.33) | P2RX7CYP2C19USP2TSHR | |
| SCHEMBL8123126 | 0.79 | — | — | |
| SCHEMBL3517313 | 0.74 | SLC6A4 (0.41) | P2RX7 | |
| Hydrochloric Acid SCHEMBL4811567 | 0.72 | SLC6A4 (0.39) | P2RX7 | |
| SCHEMBL23219353 | 0.72 | — | — | |
| SCHEMBL23219987 | 0.72 | — | — | |
| SCHEMBL27280756 | 0.70 | — | — | |
| SCHEMBL7334003 | 0.70 | — | — | |
| SCHEMBL13532071 | 0.70 | DRD2 (0.39) | P2RX7 | |
| SCHEMBL13290389 | 0.70 | SLC6A4 (0.39) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106073-B2 | Quinoline derivatives 057 | ASTRAZENECA AB (SE) | 2012-01-31 | — | — | US | disclosed |
| US-20090143428-A1 | Quinoline Derivatives 057 | ASTRAZENECA AB (SE) | 2009-06-04 | — | — | US | disclosed |
| US-7235657-B2 | Methods for preparing P2X7 inhibitors | PFIZER INC. (US) | 2007-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143428-A1 | Quinoline Derivatives 057 | CYP3A7, UGT1A7, UGT2B7 | P2RX7 64/4885CYP2C19 50/4885USP2 2057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.