Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL876773 | 0.72 | LRRK2 (0.42) | LRRK2NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL876507 | 0.69 | MAPT (0.46) | LRRK2MAPTALDH1A1KMT2A | |
| SCHEMBL876612 | 0.62 | CHRNA7 (0.46) | NPC1RAB9AKMT2ANAMPTMAPK14 | |
| SCHEMBL10225025 | 0.57 | LRRK2 (0.85) | LRRK2 | |
| SCHEMBL874150 | 0.54 | HDAC6 (0.48) | KDM4EMAPK14 | |
| SCHEMBL16708659 | 0.54 | THRB (0.47) | MAPTALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL20365093 | 0.54 | BRD4 (0.52) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL15723817 | 0.54 | BRD4 (0.50) | NPC1ALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL14009108 | 0.53 | SMYD3 (0.53) | MAPTNPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL882712 | 0.53 | HDAC6 (0.47) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |