Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | MAT2A | P31153 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL876377 | 0.85 | CHRNA7 (0.47) | CHRNA7F10NPC1RAB9AKMT2A | |
| SCHEMBL877180 | 0.84 | NAMPT (0.43) | CHRNA7HDAC6NAMPT | |
| SCHEMBL877181 | 0.80 | NAMPT (0.40) | CHRNA7HDAC6NAMPT | |
| SCHEMBL874577 | 0.76 | CHRNA7 (0.45) | CHRNA7F10NPC1RAB9AKMT2A | |
| SCHEMBL874187 | 0.76 | NPC1 (0.46) | CHRNA7NPC1RAB9AKMT2ARIPK1 | |
| SCHEMBL873877 | 0.74 | CHRNA7 (0.42) | CHRNA7NPC1RAB9ARIPK1NAMPT | |
| SCHEMBL874150 | 0.74 | HDAC6 (0.48) | BRD4HDAC6BRD2BRD3BRDT | |
| SCHEMBL874291 | 0.73 | CHRNA7 (0.39) | CHRNA7NPC1RAB9AKMT2ANAMPT | |
| SCHEMBL882629 | 0.72 | CHRNA7 (0.42) | CHRNA7NPC1RAB9AKMT2ANAMPT | |
| SCHEMBL874231 | 0.72 | CHRNA7 (0.43) | CHRNA7NPC1RAB9AKMT2ARIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |