Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 12/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5846001 | 0.77 | RAPGEF4 (0.48) | RAPGEF4GAACRHR1FFAR4LMNA | |
| SCHEMBL14473376 | 0.77 | SMN1; SMN2 (0.44) | RAPGEF4GAA | |
| SCHEMBL6666181 | 0.77 | MAPT (0.56) | LMNA | |
| SCHEMBL7339711 | 0.72 | HTT (0.55) | RAPGEF4GAAFFAR4 | |
| SCHEMBL12061338 | 0.71 | TRPV3 (0.48) | GAALMNA | |
| SCHEMBL2756366 | 0.71 | RAPGEF4 (0.57) | RAPGEF4GAAFFAR4LMNA | |
| SCHEMBL12963494 | 0.70 | RAPGEF4 (0.50) | RAPGEF4CRHR1FFAR4LMNA | |
| SCHEMBL4024420 | 0.69 | RAPGEF4 (0.36) | RAPGEF4GAAFFAR4 | |
| SCHEMBL22780718 | 0.69 | CD38 (0.38) | RAPGEF4GAALMNA | |
| SCHEMBL28382439 | 0.69 | RAPGEF4 (0.55) | RAPGEF4GAACRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10290819-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2019-05-14 | — | — | US | disclosed |
| US-20130284977-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2013-10-31 | — | — | US | disclosed |
| US-20130284977-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2013-10-31 | — | — | US | disclosed |
| WO-2012079741-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10290819-B2 | Metal complexes | PICALM, IMMT, IKZF3 | RAPGEF4 3620/4885GAA 4195/4885CRHR1 3736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.