Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL541866 | 0.83 | PIM1 (0.53) | PIM1LMNATP53ALDH1A1HPGD | |
| SCHEMBL6984795 | 0.80 | PIM1 (0.55) | PIM1LMNATP53ALDH1A1HPGD | |
| SCHEMBL30540812 | 0.80 | CA12 (0.54) | PIM1LMNATP53ALDH1A1HPGD | |
| SCHEMBL12529923 | 0.80 | CA12 (0.54) | PIM1LMNATP53ALDH1A1HPGD | |
| SCHEMBL9990974 | 0.78 | PIM1 (0.58) | PIM1LMNATP53ALDH1A1HPGD | |
| SCHEMBL18591899 | 0.78 | PIM1 (0.58) | PIM1LMNATP53ALDH1A1HPGD | |
| SCHEMBL6414543 | 0.77 | LMNA (0.62) | PIM1LMNATP53ALDH1A1HPGD | |
| SCHEMBL5866928 | 0.75 | ALDH1A1 (0.68) | PIM1LMNATP53ALDH1A1HPGD | |
| SCHEMBL4765626 | 0.75 | DRD2 (0.52) | PIM1CA2MAOBCA12CA1 | |
| SCHEMBL11457413 | 0.75 | PIM1 (0.54) | PIM1LMNATP53ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948242-B9 | CYTOTOXIC COMPOUNDS | MEDAREX INC (US) | 2012-02-08 | — | — | EP | disclosed |
| EP-1948242-B1 | CYTOTOXIC COMPOUNDS | MEDAREX INC (US) | 2011-09-14 | — | — | EP | disclosed |