SCHEMBL10067965

SCHEMBL10067965

CCOc1nc(OCC)nc(C(=O)c2cccc(F)c2NS(=O)(=O)C(F)F)n1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.37
LMNA P02545 3/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
TSHR P16473 1/20 0.34
WDR5 P61964 1/20 0.34
NLRP3 Q96P20 1/20 0.33
TP53 P04637 1/20 0.33
KAT6A Q92794 4/20 0.32
KMT2A Q03164 2/20 0.32
MEN1 O00255 1/20 0.32
HTT P42858 1/20 0.32
RXFP1 Q9HBX9 1/20 0.32
MAPK8 P45983 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA9 Q16790 1/20 0.32
DHODH Q02127 1/20 0.32
ALDH1A1 P00352 1/20 0.32
ATM Q13315 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2615681 0.88 NPC1 (0.37) MAPTKAT6AKMT2AMEN1ALDH1A1
SCHEMBL9953390 0.82 NPC1 (0.34) KAT6AKMT2AALDH1A1
SCHEMBL14582645 0.82 ALDH1A1 (0.33) KMT2AALDH1A1
SCHEMBL13044405 0.81 NPC1 (0.38) MAPTTP53KAT6AKMT2AALDH1A1
SCHEMBL13936700 0.77 MLKL (0.33) MAPTLMNA
SCHEMBL10068049 0.77 RXFP1 (0.36) KAT6ARXFP1CA1CA2CA9
SCHEMBL14445637 0.77 NPC1 (0.34) MAPTTSHRTP53KAT6AKMT2A
SCHEMBL3826176 0.76 MLKL (0.35)
SCHEMBL3834184 0.76 MLKL (0.33) MAPTKMT2AMEN1CA1CA2
SCHEMBL3803834 0.75 CASK (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9096551-B2 Method for producing 2-(triazinylcarbonyl) sulfonanilides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-08-04 US disclosed
US-9096551-B2 Method for producing 2-(triazinylcarbonyl) sulfonanilides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-08-04 US disclosed
US-9096551-B2 Method for producing 2-(triazinylcarbonyl) sulfonanilides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-08-04 US disclosed
EP-2655346-B1 PROCESS FOR THE PREPARATION OF 2-(TRIAZINYLCARBONYL)SULFONANILIDES BAYER IP GMBH (DE) 2015-01-21 EP disclosed
EP-2655346-B1 PROCESS FOR THE PREPARATION OF 2-(TRIAZINYLCARBONYL)SULFONANILIDES BAYER IP GMBH (DE) 2015-01-21 EP disclosed
US-20140024828-A1 Method for producing 2-(triazinylcarbonyl) sulfonanilides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-01-23 US disclosed
US-20140024828-A1 Method for producing 2-(triazinylcarbonyl) sulfonanilides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-01-23 US disclosed
US-20140024828-A1 Method for producing 2-(triazinylcarbonyl) sulfonanilides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-01-23 US disclosed
WO-2012084857-A2 METHOD FOR PRODUCING 2-(TRIAZINYLCARBONYL) SULFONANILIDES BAYER CROPSCIENCE AG (DE) 2012-06-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140024828-A1 Method for producing 2-(triazinylcarbonyl) sulfonanilides AOX1, SULT1E1, CBR1 MAPT 4102/4885LMNA 3282/4885L3MBTL1 4808/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.