Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13347915 | 0.89 | CHRNB2 (0.45) | CYP1A2EPHX1CHRNB2CHRNA4CHRM2 | |
| SCHEMBL140355 | 0.83 | LMNA (0.46) | CYP1A2EPHX1CHRNB2CHRNA4CHRM2 | |
| SCHEMBL27558053 | 0.83 | LMNA (0.46) | CYP1A2EPHX1CHRNB2CHRNA4CHRM2 | |
| SCHEMBL21344297 | 0.83 | LMNA (0.46) | CYP1A2EPHX1CHRNB2CHRNA4CHRM2 | |
| SCHEMBL21098353 | 0.81 | CHRNB2 (0.44) | CYP1A2EPHX1CHRNB2CHRNA4CHRM2 | |
| SCHEMBL10068346 | 0.81 | SMN1; SMN2 (0.54) | EPHX1CHRNB2CHRNA4SMN1; SMN2KDM4E | |
| SCHEMBL19853430 | 0.81 | CHRNB2 (0.44) | CYP1A2EPHX1CHRNB2CHRNA4CHRM2 | |
| SCHEMBL12999571 | 0.81 | SMN1; SMN2 (0.42) | CHRNB2CHRNA4SMN1; SMN2LMNAKDM4E | |
| SCHEMBL20075983 | 0.80 | EPHX1 (0.45) | CYP1A2EPHX1CHRNB2CHRNA4CHRM2 | |
| SCHEMBL13662404 | 0.78 | CYP1A2 (0.47) | CYP1A2EPHX1CHRNB2CHRNA4CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3609888-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | Metacrine, Inc. (US) | 2020-02-19 | — | — | EP | claimed |
| WO-2018170182-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | METACRINE, INC. (US) | 2018-09-20 | — | — | WO | claimed |
| US-11236071-B1 | Farnesoid X receptor agonists and uses thereof | METACRINE, INC. (US) | 2022-02-01 | — | — | US | disclosed |
| US-8097741-B2 | Hybrid coatings prepared from glycidyl carbamate resins | NDSU RESEARCH FOUNDATION (US) | 2012-01-17 | — | — | US | disclosed |
| US-20110288230-A1 | METHOD FOR PREPARING POLYHYDROXY-URETHANES | RHODIA OPERATIONS (FR) | 2011-11-24 | — | — | US | disclosed |
| US-20110288230-A1 | METHOD FOR PREPARING POLYHYDROXY-URETHANES | RHODIA OPERATIONS (FR) | 2011-11-24 | — | — | US | disclosed |
| US-8017719-B2 | Method for preparing polyhydroxy-urethanes | RHODIA OPERATIONS (FR) | 2011-09-13 | — | — | US | disclosed |
| US-8017719-B2 | Method for preparing polyhydroxy-urethanes | RHODIA OPERATIONS (FR) | 2011-09-13 | — | — | US | disclosed |
| US-7846638-B2 | Composition for forming anti-reflective coating for use in lithography | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2010-12-07 | — | — | US | disclosed |
| US-20090312502-A1 | Method for preparing polyhydroxy-urethanes | RHODIA OPERATIONS (FR) | 2009-12-17 | — | — | US | disclosed |
| US-20090312502-A1 | Method for preparing polyhydroxy-urethanes | RHODIA OPERATIONS (FR) | 2009-12-17 | — | — | US | disclosed |
| US-7425399-B2 | Composition for forming anti-reflective coating for use in lithography | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2008-09-16 | — | — | US | disclosed |
| WO-2008107568-A2 | METHOD FOR PREPARING POLYHYDROXY-URETHANES | RHODIA OPERATIONS (FR) | 2008-09-12 | — | — | WO | disclosed |
| US-20080206680-A1 | Composition for forming anti-reflective coating for use in lithography | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11236071-B1 | Farnesoid X receptor agonists and uses thereof | NR1H4, NR1H2, NR1H3 | CYP1A2 494/4885EPHX1 369/4885CHRNB2 1769/4885 |
| US-20110288230-A1 | METHOD FOR PREPARING POLYHYDROXY-URETHANES | UROD, HPD, ALKBH3 | CYP1A2 421/4885EPHX1 999/4885CHRNB2 4550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.