Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10040019 | 0.92 | ALDH1A1 (0.52) | ALDH1A1POLBNPC1PTK2BHIF1A | |
| SCHEMBL8752544 | 0.82 | KMT2A (0.51) | ALDH1A1POLBMEN1KMT2AL3MBTL1 | |
| SCHEMBL18486629 | 0.81 | MEN1 (0.61) | ALDH1A1POLBMEN1KMT2ANPSR1 | |
| SCHEMBL10796240 | 0.78 | HIF1A (0.59) | ALDH1A1POLBNPC1PTK2BHIF1A | |
| SCHEMBL17488973 | 0.74 | ALDH1A1 (1.00) | ALDH1A1POLBNPC1PTK2BHIF1A | |
| SCHEMBL31482562 | 0.74 | KMT2A (0.54) | ALDH1A1POLBMEN1KMT2AL3MBTL1 | |
| SCHEMBL4455340 | 0.74 | MEN1 (0.54) | ALDH1A1POLBMEN1KMT2AL3MBTL1 | |
| SCHEMBL3890445 | 0.74 | KMT2A (0.54) | ALDH1A1POLBMEN1KMT2AL3MBTL1 | |
| SCHEMBL10039996 | 0.74 | PTK2B (0.89) | ALDH1A1POLBNPC1PTK2BHIF1A | |
| SCHEMBL780087 | 0.73 | MEN1 (0.53) | ALDH1A1POLBMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3251677-A2 | PHOSPHATE MANAGEMENT WITH SMALL MOLECULES | OPKO Ireland Global Holdings, Limited (IE) | 2017-12-06 | — | — | EP | disclosed |
| EP-2389183-B1 | PHOSPHATE MANAGEMENT WITH SMALL MOLECULES | OPKO IRELAND GLOBAL HOLDINGS LTD (IE) | 2017-05-31 | — | — | EP | disclosed |
| US-9198923-B2 | Phosphate management with small molecules | Opko Ireland Global Holdings, Ltd. (KY) | 2015-12-01 | — | — | US | disclosed |
| US-20120028926-A1 | Phosphate Management with Small Molecules | CYTOCHROMA INC. (CA) | 2012-02-02 | — | — | US | disclosed |
| WO-2010083613-A1 | PHOSPHATE MANAGEMENT WITH SMALL MOLECULES | CYTOCHROMA INC. (CA) | 2010-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028926-A1 | Phosphate Management with Small Molecules | SLC34A2, PHPT1, SLC34A3 | ALDH1A1 3931/4885POLB 1771/4885NPC1 407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.