Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 5/20 | 0.35 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 2/20 | 0.35 |
| ▸ | TACR1 | P25103 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.32 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.32 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10069606 | 0.92 | ALDH1A1 (0.37) | ALDH1A1IDH1ERCC5FEN1LMNA | |
| SCHEMBL10069602 | 0.90 | ALDH1A1 (0.39) | ALDH1A1ERCC5FEN1LMNAMAPK1 | |
| SCHEMBL10069590 | 0.90 | ALDH1A1 (0.39) | ALDH1A1IDH1ERCC5FEN1LMNA | |
| SCHEMBL10069598 | 0.90 | TP53 (0.33) | BRD4GRM5 | |
| SCHEMBL8430943 | 0.88 | ALDH1A1 (0.39) | ALDH1A1TACR1LMNAAPPBRD4 | |
| SCHEMBL10069591 | 0.86 | ESR1 (0.35) | ALDH1A1IDH1ERCC5FEN1LMNA | |
| SCHEMBL10069594 | 0.85 | MAPT (0.38) | ALDH1A1ERCC5FEN1LMNAERCC1 | |
| SCHEMBL10069601 | 0.85 | ALDH1A1 (0.36) | ALDH1A1ERCC5FEN1MAPK1GRM5 | |
| SCHEMBL1687626 | 0.84 | ALDH1A1 (0.38) | ALDH1A1IDH1ERCC5FEN1TACR1 | |
| SCHEMBL10069625 | 0.84 | ALDH1A1 (0.41) | ALDH1A1IDH1ERCC5FEN1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047993-A2 | N-HYDROXYPYRIMIDINE-2,4-DIONES AS INHIBITORS OF HIV AND HCV | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2012-04-12 | — | — | WO | disclosed |