Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.72 |
| ▸ | VCP | P55072 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | CES2 | O00748 | 2/20 | 0.56 |
| ▸ | CES1 | P23141 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.50 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10069797 | 0.93 | APP (0.72) | APPVCPMEN1KMT2ANPC1 | |
| SCHEMBL10069794 | 0.91 | APP (0.84) | APPVCPMEN1KMT2ANPC1 | |
| SCHEMBL10625119 | 0.86 | VCP (0.81) | APPVCPMEN1KMT2ANPC1 | |
| SCHEMBL27167232 | 0.85 | APP (0.75) | APPVCPNPC1RAB9ACES2 | |
| SCHEMBL28695966 | 0.85 | APP (0.75) | APPVCPNPC1RAB9ACES2 | |
| SCHEMBL28629549 | 0.84 | APP (0.73) | APPVCPCES2CES1 | |
| SCHEMBL10170737 | 0.84 | APP (0.73) | APPVCPCES2CES1 | |
| SCHEMBL28972824 | 0.84 | APP (0.73) | APPVCPMEN1KMT2ANPC1 | |
| SCHEMBL28972914 | 0.84 | APP (0.73) | APPVCPRAB9AALDH1A1MAPT | |
| SCHEMBL9193189 | 0.83 | FFAR1 (0.60) | APPNPC1RAB9APOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11691135-B2 | Synthesis of alkynones via carbonylative Sonogashira coupling reactions catalyzed by Pd(II)-N-Heterocyclic carbene-pyridine complexes | KING FAHD UNIVERSITY OF PETROLEUM & MINERALS (SA) | 2023-07-04 | — | — | US | disclosed |
| CN-115677739-A | Preparation method of O, O-boron difluoride complex | 华南理工大学 | 2023-02-03 | — | — | CN | disclosed |
| US-20220411451-A1 | ACTIVE HETEROGENIZED PALLADIUM-BRIDGED-NHC CATALYSTS FOR CARBONYLATIVE SONOGASHIRA COUPLING REACTIONS | KING FAHD UNIVERSITY OF PETROLEUM & MINERALS (SA) | 2022-12-29 | — | — | US | disclosed |
| CN-113429280-B | Method for preparing chalcone compounds by selective hydrogenation reduction of alkynone under catalysis of Ti (III) complex | 陕西师范大学 | 2022-08-23 | — | — | CN | disclosed |
| US-20220118435-A1 | SYNTHESIS OF ALKYNONES VIA CARBONYLATIVE SONOGASHIRA COUPLING REACTIONS CATALYZED BY PD(II)-N-HETEROCYCLIC CARBENE-PYRIDINE COMPLEXES | KING FAHD UNIVERSITY OF PETROLEUM & MINERALS (SA) | 2022-04-21 | — | — | US | disclosed |
| CN-110452270-B | Azacarbene palladium complex crystal, synthesis method thereof and application thereof in preparation of alpha, beta-unsaturated ketone compound | 陕西师范大学 | 2022-02-25 | — | — | CN | disclosed |
| CN-113429280-A | Method for preparing chalcone compounds by selective hydrogenation reduction of alkynone under catalysis of Ti (III) complex | 陕西师范大学 | 2021-09-24 | — | — | CN | disclosed |
| CN-109810147-B | Pyrene-labeled benzimidazole nitrogen heterocyclic carbene palladium metal complex, and preparation and application thereof | 中国科学院兰州化学物理研究所 | 2021-02-26 | — | — | CN | disclosed |
| CN-108148064-B | Method for preparing pyrazole quinoxalinone derivative | 浙江百斯特化工有限公司 | 2020-06-26 | — | — | CN | disclosed |
| CN-101456801-B | Method for synthesizing alpha-beta unsaturated acetyenic ketone compounds by carbonylation | LANZHOU CHEM PHYS INST | 2012-07-04 | — | — | CN | disclosed |
| WO-2012016619-A1 | PHENETHYL, PHENETHYLENE, PHENETHYNE AND INDANONE DERIVATES IN COSMETIC FORMULATIONS, ESPECIALLY FOR USE IN SKIN AGEING PROCESSES | MERCK PATENT GMBH (DE) | 2012-02-09 | — | — | WO | disclosed |
| CN-101456801-A | Method for synthesizing alpha-beta unsaturated acetyenic ketone compounds by carbonylation | LANZHOU CHEM PHYS INST (CN) | 2009-06-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11691135-B2 | Synthesis of alkynones via carbonylative Sonogashira coupling reactions catalyzed by Pd(II)-N-Heterocyclic carbene-pyridine complexes | PDK2, SNCA, YAP1 | APP 4235/4885VCP 4072/4885MEN1 1330/4885 |
| US-20220411451-A1 | ACTIVE HETEROGENIZED PALLADIUM-BRIDGED-NHC CATALYSTS FOR CARBONYLATIVE SONOGASHIRA COUPLING REACTIONS | NDC1, SMARCC2, SMARCC1 | APP 4667/4885VCP 3513/4885MEN1 1498/4885 |
| US-20220118435-A1 | SYNTHESIS OF ALKYNONES VIA CARBONYLATIVE SONOGASHIRA COUPLING REACTIONS CATALYZED BY PD(II)-N-HETEROCYCLIC CARBENE-PYRIDINE COMPLEXES | PDK2, SNCA, YAP1 | APP 4235/4885VCP 4072/4885MEN1 1330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.