⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8516519 | 0.79 | TLR8 (0.50) | — | |
| SCHEMBL30267411 | 0.78 | — | — | |
| SCHEMBL17077928 | 0.78 | — | — | |
| SCHEMBL9963192 | 0.78 | BRD4 (0.40) | — | |
| SCHEMBL26750142 | 0.78 | DRD2 (0.37) | — | |
| SCHEMBL13975421 | 0.77 | TLR8 (0.49) | — | |
| SCHEMBL11964124 | 0.76 | LMNA (0.38) | — | |
| SCHEMBL10070301 | 0.74 | — | — | |
| SCHEMBL9749715 | 0.74 | ADORA2B (0.37) | — | |
| SCHEMBL27465054 | 0.74 | ADORA2B (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022056447-A1 | CARBOXYLIC ACID-CONTAINING COMPOUNDS AS MODULATORS OF BIS-PHOSPHOGLYCERATE MUTASE FOR THE TREATMENT OF SICKLE CELL DISEASE | GENZYME CORPORATION (US) | 2022-03-17 | — | — | WO | disclosed |
| WO-2021034863-A1 | CHEMICAL DERIVATIVES AND METHODS FOR SYNTHESIZING AND COMPOUNDING CHEMICAL DERIVATIVES RELATED TO CAPSAICIN PALMITATE AND CAPSAICIN PRODRUGS | CHORDA PHARMA, INC. (US) | 2021-02-25 | — | — | WO | disclosed |
| US-9593107-B2 | Dihydroquinoline-2-one derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-03-14 | — | — | US | disclosed |
| US-20150376180-A1 | DIHYDROQUINOLINE-2-ONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-12-31 | — | — | US | disclosed |
| WO-2015110024-A1 | OXAZOLIDINONE COMPOUNDS AND THEIR USES IN PHARMACEUTICALS | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2015-07-30 | — | — | WO | disclosed |
| US-8501786-B2 | Hydroxymethyl pyrrolidines as beta 3 adrenergic receptor agonists | MERCK SHARP & DOHME CORP. (US) | 2013-08-06 | — | — | US | disclosed |
| US-8324186-B2 | 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of CCR2 | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-12-04 | — | — | US | disclosed |
| US-20120022053-A1 | Oxadiazine Derivatives | SYNGENTA CROP PROTECTION, INC. (US) | 2012-01-26 | — | — | US | disclosed |
| US-8097708-B2 | 10a-Azalide compound | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2012-01-17 | — | — | US | disclosed |
| US-8097708-B2 | 10a-Azalide compound | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2012-01-17 | — | — | US | disclosed |
| US-20100267668-A1 | 4-AZETIDINYL-1-HETEROATOM LINKED-CYCLOHEXANE ANTAGONISTS OF CCR2 | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-10-21 | — | — | US | disclosed |
| US-7655650-B2 | Oxadiazine derivatives | Syngenta Corporation (US) | 2010-02-02 | — | — | US | disclosed |
| US-20090281292-A1 | 10a-Azalide Compound | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2009-11-12 | — | — | US | disclosed |
| US-20090281292-A1 | 10a-Azalide Compound | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2009-11-12 | — | — | US | disclosed |
| WO-2009123870-A1 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK & CO., INC. (US) | 2009-10-08 | — | — | WO | disclosed |
| US-20090111822-A1 | 1,2,3-TRIAZOLE PYRROLIDINE DERIVATIVES AS MODULATORS OF MGLUR5 | ASTRAZENECA AB (SE) | 2009-04-30 | — | — | US | disclosed |
| US-7375101-B2 | Benzodiazepine derivatives, preparation thereof and use thereof | ASTRAZENECA AB (SE) | 2008-05-20 | — | — | US | disclosed |
| US-20070219188-A1 | Oxadiazine Derivatives | SYNGENTA CROP PROTECTION, INC. (US) | 2007-09-20 | — | — | US | disclosed |
| EP-0333832-A1 | ARTIFICIAL DNA BASE PAIR ANALOGUES | TEMPLE UNIVERSITY (US) | 1989-09-27 | — | — | EP | disclosed |
| WO-1989002921-A1 | ARTIFICIAL DNA BASE PAIR ANALOGUES | TEMPLE UNIVERSITY (US) | 1989-04-06 | — | — | WO | disclosed |